Category: 112671-42-8

Application of 112671-42-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 112671-42-8 as follows.

Under nitrogen conditions, 7H-dibenzo[c,g]carbazole (12.8 g, 47.8 mmol),4-bromo-1-iodo-2-nitrobenzene (17.2 g, 52.6 mmol), cesium carbonate (13.8 g, 71.7 mmol) was stirred in a solvent of dimethyl sulfoxide. After stirring at room temperature for about 2 hours, Raise the temperature to 60 C and stir for 8 hours. Extracted three times with dichloromethane and deionized water, after rotary evaporation, dry over anhydrous MgSO4 and recrystallize the compound from dichloromethane/methanol.Intermediate 1-1 (19 g, 85%) was obtained.

According to the analysis of related databases, 112671-42-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Jilin Aolaide Optoelectric Materials Co., Ltd.; Suo Hongguang; Wang Jinzheng; Jiang Zhiyuan; He Jinxin; Jiang Xiaochen; Jin Furong; (15 pag.)CN109422757; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, molecular formula is C6H3BrINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H3BrINO2

Under the protection of argon, 1-naphthalene boronic acid (22.0 g, 128.1 mmol), 4-bromo-1-iodo-2-nitrobenzene (35.0 g, 106.8 mmol) and Na2CO3 (34.0 g, were sequentially added to the reaction flask. 320.4 mmol), tetrakistriphenylphosphine palladium (6.17 g, 5.3 mmol), toluene (640 ml) and ethanol (160 ml), and the mixture was stirred at 90 C for 3 hours. After the stirring was completed, distilled water (160 ml) was poured, and the mixture was cooled to room temperature, the organic phase was extracted with ethyl acetate, and the organic phase was concentrated to give compound B1 (30 g, 86%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 112671-42-8, its application will become more common.

Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Zhou Wenting; Cai Hui; (39 pag.)CN108822020; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 4-Bromo-1-iodo-2-nitrobenzene

Dissolving 50 g of 2-naphthalene boronic acid, 94 g of 2-nitro-4-bromo-1-iodobenzene, and 10 g of Pd(PPh3)4 In a mixed solvent of 300 mL of THF and 50 mL of H2O, the mixture was reacted at 80 C for 24 hours under a nitrogen atmosphere. The solvent was dried and extracted with dichloromethane.Washing liquid, column chromatography to obtain intermediate M2.

The synthetic route of 112671-42-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangzhou Huarui Optoelectric Materials Co., Ltd.; Pan Junyou; Zhang Chen; Jiang Guangtao; You Xueqiang; Huang Hong; (40 pag.)CN109705100; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, A new synthetic method of this compound is introduced below., COA of Formula: C6H3BrINO2

To a solution of 4-bromo-1 -iodo-2-nitrobenzene (66 g, 0.2 mol) in MeOH (700 mL) was added stannous chloride (226 g, 1 mol) at 0 C. The resultant mixture was heated to reflux (80 C) for 4 h. The solvent was removed under reduced pressure, and then the residue was diluted with ethyl acetate (1 L), washed with H2O (1 L), dried over sodium sulfate, concentrated to give a residue which was purified by column chromatography (eluent: petroleum ether: ethyl acetate= 20:1 ) to give 5-bromo-2-iodoaniline (39 g, 65%) as a white solid. LCMS (Method B): 2.27 min m/z [MH]+=298.1 ; 300.1

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; CATALYST THERAPEUTICS PTY LTD; BURNS, Chris; GARNIER, Jean-Marc; SHARP, Phillip Patrick; FEUTRILL, John; CUZZUPE, Anthony; (140 pag.)WO2017/20086; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

112671-42-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, This compound has unique chemical properties. The synthetic route is as follows.

mixture of compound 71 (6.5 g, 19.8 mmol) and Fe (4.98 g, 89.2 mmol) inCH3COOH (30 mL) and CH3CH2OH (30 mL), was refluxed for 1.5 hours. The mixture was cooled to room temperature and after addition of saturated NaHC03 (aq.), extracted with ethyl acetate (3 x 150 mL).The combined organic layer was separated, dried over Na2S04 and the solvent was removed in vacuo, resulting in compound 72 (5.9 g). Method A2; Rt: 1.17 min. m/z=: 299.6 (M+H)+ Exact mass: 298.9

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; TIBOTEC PHARMACEUTICALS; VANDYCK, Koen; VERSCHUEREN, Wim Gaston; RABOISSON, Pierre Jean-Marie Bernard; WO2012/13643; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

112671-42-8, Adding some certain compound to certain chemical reactions, such as: 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112671-42-8.

General procedure: The appropriate 4-substituted-1-iodo-2-nitrobenzene 10 (1mmol), appropriate 1,3-disubstituted-5-aminopyrazole 11 (1.3mmol), and anhydrous potassium carbonate (248mg, 1.8mmol) were heated in the presence of rac-BINAP (23mg, 0.036mmol, 3.7mol%), Pd2dba3 (23mg, 0.024mmol, 2.5mol%), and 18-crown-6 (10mg, 0.038mmol) in toluene (8mL, purged with argon) at 100C. The reaction was carried out under argon for 24h. After cooling the reaction mixture was filtered and purified using column chromatography on aluminium oxide with toluene, or a toluene-ethyl acetate mixture (10:1) as an eluent. The product was recrystallized from toluene.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 112671-42-8.

Reference:
Article; Danel, Andrzej; Wojtasik, Katarzyna; Szlachcic, Pawe?; Gryl, Marlena; Stadnicka, Katarzyna; Tetrahedron; vol. 73; 34; (2017); p. 5072 – 5081;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

112671-42-8,Some common heterocyclic compound, 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, molecular formula is C6H3BrINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate Ml-a (5. lg, 18.4 mmol) and 2_p_5_ nitrobenzene (15.3 g, 46.7 mmol), tert-butanol sodium (7. lg, 74.4 mmol), toluene 100 mL, nitrogen Protection, 0.3g Pd2 (dba) 3, tri-tert-butylphosphine (20ml, 10% toluene solution), start stirring, heat to 100 C reflux, reaction 12h, the reaction liquid is washed, the organic phase is concentrated, passed through the silica gel column, rinse The oil was petroleum ether: ethyl acetate = 50:1, and the eluent was concentrated to give intermediate Ml-b (9.2 g, yield: 7.39 %).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-1-iodo-2-nitrobenzene, its application will become more common.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Fan Hongtao; Zhang Yaguang; Zhang Xianghui; Ren Xueyan; (28 pag.)CN108341826; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

112671-42-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The starting material, phenylboronic acid (76.84g, 630.2mmol) was dissolved in a THF (2780ml) in a round bottom flask, 4-bromo-1-iodo-2-nitrobenzene (309.96g, 945.3mmol), Pd (PPh3) 4 ( 36.41g, 31.5mmol), was added K2CO3 (261.3g, 1890.6mmol), water (1390ml) and the resulting mixture was stirred at 80 . Once the reaction is complete, the organic layer extracted with water and CH2Cl2After the dried over MgSO4 and concentrated to a silicagel column and the resulting compound was recrystallized 122.68g product (yield: 70%)It was obtained.

The synthetic route of 4-Bromo-1-iodo-2-nitrobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Duksan Neolux Co, Ltd.; Moon, Song Yoon; Lee, Son Hui; Park, Jong Cheol; Kim, Dae Song; Lee, Bom Song; Park, Song Jae; (89 pag.)KR101550768; (2015); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

112671-42-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, This compound has unique chemical properties. The synthetic route is as follows.

9.9-dimethyl acridine (10 g, 47.8 mmol) under nitrogen4-bromo-1-iodo-2-nitrobenzene (32.74 g, 99.85 mmol),Potassium carbonate (13.8 g, 99.85 mmol), copper (6.35 g, 99.85 mmol),Ethylene glycol (350 ml) was stirred, and the reaction was stirred at about 100 C for about 1 hour.It was extracted with acetone, and the organic layer was taken, and a hydrochloric acid solution (hydrochloric acid: deionized water = 1:10 vol.%) (500 ml) was added.After washing with deionized water,Recrystallization of acetone and methanol,Intermediate 1-1 (12 g, 59%) was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Jilin Aolaide Optoelectric Materials Co., Ltd.; Jin Furong; He Jinxin; Wang Shikai; (16 pag.)CN108727374; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

112671-42-8, Name is 4-Bromo-1-iodo-2-nitrobenzene, 112671-42-8, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

(1) Take (100mmol) N-phenylcarbazole-1-boronic acid,32.6g (100mmol) of 2-iodo-5-bromonitrobenzene,(1%) Pd (PPh3) 4,40g (300mmol) sodium carbonate,Toluene (800mL),Ethanol (200 mL) and water (200 mL),Heated to reflux, reacted for 8h, the reaction was completed;The reaction solution was extracted with ethyl acetate, and the organic phase was concentrated.A yellow solid A was obtained;

Statistics shows that 4-Bromo-1-iodo-2-nitrobenzene is playing an increasingly important role. we look forward to future research findings about 112671-42-8.

Reference:
Patent; Yantai Xianhua Chemical Technology Co., Ltd.; Xing Qifeng; Feng Peichuan; Chen Yue; Hu Lingfeng; Chen Yili; (28 pag.)CN110698458; (2020); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com