Category: 112671-42-8

Application of 112671-42-8,Some common heterocyclic compound, 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, molecular formula is C6H3BrINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The starting material, phenylboronic acid (76.84g, 630.2mmol) was dissolved in a THF(2780ml) in a round bottom flask, 4-bromo-1-iodo-2-nitrobenzene (309.96g,945.3mmol), Pd (PPh3) 4 ( was added 36.41g, 31.5mmol), K2CO3 (261.3g,1890.6mmol), water (1390ml) and the resulting mixture was stirred at 80 C. After the reaction was completed CH2Cl2 and water, the organic layer was dried overMgSO4, and extracted with silicagel column and re-crystallization and the resultingcompound and then concentrated to give 122.68g product (yield: 70%) was obtained.

The synthetic route of 112671-42-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Duksan Neolux Co. Ltd.; Moon, Song Yun; Lee, Son Hui; Park, Jong Cheol; Kim, Dae Song; Lee, Bom Song; Kim, Seok Hyeon; (113 pag.)KR2015/98171; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 112671-42-8,Some common heterocyclic compound, 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, molecular formula is C6H3BrINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) In the reaction bottle, add N-phenylcarbazole-4-boronic acid (100mmol), 2-iodo-5-bromonitrobenzene (100mmol), 0.9g (0.785mmol, 0.5%) tetratriphenylphosphine Palladium, toluene 500mL, ethanol 200mL, water 200mL, and potassium carbonate 40g (300mmol), react at 100 C for 8h; after the reaction is complete, stop the reaction; cool to room temperature, separate the organic phase, concentrate, silica gel column chromatography to obtain yellow powder M1;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-1-iodo-2-nitrobenzene, its application will become more common.

Reference:
Patent; Yantai Xianhua Chemical Technology Co., Ltd.; Xing Qifeng; Feng Peichuan; Chen Yue; Hu Lingfeng; Chen Yili; (24 pag.)CN110734446; (2020); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Bromo-1-iodo-2-nitrobenzene

Intermediate M2-b (4.8 g, 15 mmol),2-Iodo-5-bromonitrobenzene (5.9 g, 18 mmol), sodium tert-butoxide(2.9g, 30mmol), toluene 50mL, nitrogen protection,0.17 g of Pd2(dba)3, tri-tert-butylphosphine(11ml, 10% toluene solution), stirring turned on,Heated to 100 C reflux, reaction 12h, the reaction solution washed,The organic phase was concentrated and passed through a silica gel column. The eluent was petroleum ether:Ethyl acetate = 50:1, concentrated rinse,Intermediate M2-c (6.6 g, 84.6% yield) was obtained.

According to the analysis of related databases, 112671-42-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Fan Hongtao; Xing Qifeng; Zhang Wei; Zhang Xianghui; (38 pag.)CN107880049; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112671-42-8, Safety of 4-Bromo-1-iodo-2-nitrobenzene

4-bromo-l-iodo-2-nitrobenzene (3 g, 9.18 mmol) was dissolved in anhydrous THF (20 mL) under N2 atmosphere, and the flask was cooled to -78 C. The mixture was stirred for 5 minutes and n-BuLi (4.4 mL, 2.5mol/L) was slowly added. The reaction mixture turned dark and stirring was continued at -78C for 15 minutes. Then, compound OA-1 (1.92 g, 11 mmol) was slowly added to the mixture. The reaction was stirred for 30 minutes at-78 C and then warmed to room temperature. The mixture was poured into water (50 mL) and extracted with CH2CI2 (2 x 20 mL). The organic phases were separated and washed with brine, dried over Na2S04 and concentrated to dryness. The resulting residue was purified by silica gel column chromatography (eluent: petroleum ether/ ethyl acetate = 3/1), resulting in compound OA-2 (1.3 g, 38 % yield). Method A2; Rt: 1.04 min. m/z=: 378.7 (M+H)+ Exact mass: 378.0

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-iodo-2-nitrobenzene, and friends who are interested can also refer to it.

Reference:
Patent; JANSSEN R&D IRELAND; VANDYCK, Koen; VERSCHUEREN, Wim, Gaston; RABOISSON, Pierre, Jean-Marie, Bernard; WO2013/98313; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112671-42-8, Recommanded Product: 4-Bromo-1-iodo-2-nitrobenzene

Under nitrogen conditions, 7H-diphenyl[c,g]carbazole (13.3 g, 49.92 mmol),4-bromo-1-iodo-2-nitrobenzene (32.74 g, 99.85 mmol),Potassium carbonate (13.8 g, 99.85 mmol), copper (6.35 g, 99.85 mmol),Stirring with ethylene glycol (350ml) at 100 CAfter stirring for about 1 hour, the reaction was completed, and after washing with deionized water,Recrystallization of acetone and methanol gave Intermediate 1-1 (15.9 g, 68%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-iodo-2-nitrobenzene, and friends who are interested can also refer to it.

Reference:
Patent; Jilin Aolaide Optoelectric Materials Co., Ltd.; He Jinxin; Jiang Zhiyuan; Jiang Xiaochen; Suo Hongguang; Wang Jinzheng; Jin Furong; (14 pag.)CN109422756; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 112671-42-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 112671-42-8 as follows.

Intermediate M3-a (3.7 g, 18.6 mmol) and 2-iodo-5-bromonitrobenzene (15.3 g, 46.7 mmol), sodium tert-butoxide(7.1 g, 74.4 mmol), 100 mL of toluene, nitrogen protection, Pd2 (dba) 3 (0.3 g),Tri-tert-butylphosphine (20ml, 10% in toluene), stirring, heating to 100 C reflux, reaction 12h, the reaction liquid was washed, the organic phase was concentrated, passed the silica gel column,The eluent is petroleum ether: ethyl acetate = 50:1, concentrated eluent,Intermediate M3-b (9.2 g, yield 82.7%) was obtained.

According to the analysis of related databases, 112671-42-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Fan Hongtao; Zhang Yaguang; Zhang Xianghui; Ren Xueyan; (36 pag.)CN108440543; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112671-42-8, name: 4-Bromo-1-iodo-2-nitrobenzene

Intermediate M1 – a (5.1 g, 18.4 mmol) with 2 – iodo -5 – bromo nitrobenzene (15.3 g, 46.7 mmol), sodium tertiary butyl alcohol (7.1 g, 74.4 mmol), toluene 100 ml, nitrogen protection, 0.3 gPd2(Dba)3, Tri-[…] (20 ml, 10% toluene solution), open mixing, heating to 100 C reflux, the reaction 12 h, washing the reaction solution, the organic phase is concentrated, over silica gel column, eluent ethyl acetate is petroleum ether=50 1, concentrated eluent, get midbody M1 – b (9.2 g, yield 73.9%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-iodo-2-nitrobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Fan Hongtao; Xing Qifeng; Zhang Wei; Zhang Xianghui; (25 pag.)CN107880051; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, molecular formula is C6H3BrINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H3BrINO2

(1) Take (100mmol) 4- (9,9-dimethylphosphonium) boronic acid,32.6g (100mmol) of 2-iodo-5-bromonitrobenzene,(1%) Pd (PPh3) 4,40g (300mmol) sodium carbonate,Toluene (800mL),Ethanol (200 mL) and water (200 mL),Heated to reflux, reacted for 8h, the reaction was completed;The reaction solution was extracted with ethyl acetate, and the organic phase was concentrated.A yellow solid A was obtained;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 112671-42-8, its application will become more common.

Reference:
Patent; Yantai Xianhua Chemical Technology Co., Ltd.; Xing Qifeng; Feng Peichuan; Chen Yue; Hu Lingfeng; Chen Yili; (28 pag.)CN110698458; (2020); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112671-42-8, SDS of cas: 112671-42-8

Under the protection of argon, dibenzothiophene-4-boronic acid (29.2 g, 128.1 mmol), 4-bromo-1-iodo-2-nitrobenzene (35.0 g, 106.8 mmol), Na2CO3 were sequentially added to the reaction flask. (34.0 g, 320.4 mmol), tetrakistriphenylphosphine palladium (6.17 g, 5.3 mmol), toluene (640 ml) and ethanol (160 ml), and the reaction mixture was stirred at 90 C for 3 hours. After the stirring was completed, poured into distilled water (160 ml), cooled to room temperature, and the organic phase was extracted with ethyl acetate.The organic phase is concentrated and combined by column chromatographyC5 (33.6 g, 82%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Zhou Wenting; Cai Hui; (39 pag.)CN108822020; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112671-42-8, SDS of cas: 112671-42-8

Under the protection of argon, dibenzothiophene-4-boronic acid (29.2 g, 128.1 mmol), 4-bromo-1-iodo-2-nitrobenzene (35.0 g, 106.8 mmol), Na2CO3 were sequentially added to the reaction flask. (34.0 g, 320.4 mmol), tetrakistriphenylphosphine palladium (6.17 g, 5.3 mmol), toluene (640 ml) and ethanol (160 ml), and the reaction mixture was stirred at 90 C for 3 hours. After the stirring was completed, poured into distilled water (160 ml), cooled to room temperature, and the organic phase was extracted with ethyl acetate.The organic phase is concentrated and combined by column chromatographyC5 (33.6 g, 82%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Zhou Wenting; Cai Hui; (39 pag.)CN108822020; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com