Category: 1096481-48-9

On February 4, 2021, Schenkel, Laurie B.; Vasbinder, Melissa Marie; Kuntz, Kevin Wayne; Perl, Nicholas Robert; Downing, Jennifer published a patent.Product Details of 1096481-48-9 The title of the patent was Preparation of pyrazolopyrimidine carboxamides and related heterobicyclic amides as inhibitors of CD38 useful in the treatment of cancer. And the patent contained the following:

The invention relates to preparation of pyrazolopyrimidine carboxamides and related heterobicyclic amides(I) which are inhibitors of CD38 and are useful in the treatment of cancer. Compounds I wherein V is N or CRv; Rv is H, halo, or C1-4 alkyl; W is N or CRw; Rw is H, halo, or C1-4 alkyl;; Ring A is a 5-membered heteroaryl group having 1, 2 or 3 ring-forming heteroatoms selected from N, O, and S; L is a C1-4 alkylene linker; n is 0 or 1; Q is H, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, etc.; etc…, are claimed. The example compound II was prepared via 3-steps synthesis using imidazole as starting material (procedure given). Compounds I were evaluated for their biol. activity (data given). Compounds I can be useful in treatment of cancers. The experimental process involved the reaction of Methyl 2-amino-5-iodo-3-methylbenzoate(cas: 1096481-48-9).Product Details of 1096481-48-9

The Article related to pyrazolopyrimidine carboxamide preparation cd38 inhibitor antitumor cancer, heterobicyclic amide preparation cd38 inhibitor antitumor cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 1096481-48-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On February 1, 2016, Beaudegnies, Renaud; Quaranta, Laura; Murphy Kessabi, Fiona; Lamberth, Clemens; Knauf-Beiter, Gertrud; Fraser, Torquil published an article.Category: iodides-buliding-blocks The title of the article was Synthesis and anti-oomycete activity of novel quinazolin- and benzothiazol-6-yloxyacetamides: Potent aza-analogs and five-ring analogs of quinoline fungicides. And the article contained the following:

Synthesis and anti-oomycete activity of quinazolines, e.g., I and benzothiazol-6-yloxyacetamide II was described. The synthesized compounds showed excellent in vivo activity against the three economically most important oomycete pathogens Phytophthora infestans, Plasmopara viticola and Pythium ultimum. These were polar analogs of known quinolin-6-yloxyacetamides, which were not active against the soil-borne damping-off disease caused by Pythium ultimum. The Bogert quinazoline synthesis, proved to be highly useful for the concise construction of required quinazolin-6-ol building blocks. The experimental process involved the reaction of Methyl 2-amino-5-iodo-3-methylbenzoate(cas: 1096481-48-9).Category: iodides-buliding-blocks

The Article related to preparation quinazoline benzothiazolyloxyacetamide anti oomycete sar, benzothiazole, crop protection, fungicide, heterocycle, quinazoline, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On January 8, 2009, Annis, Gary David published a patent.Formula: C9H10INO2 The title of the patent was Process for preparing 2-amino-5-cyanobenzoic acid derivatives using nickel-catalyzed cyanation reaction. And the patent contained the following:

Disclosed is a method for preparing a compound of formula I (X = CN; R1 = NHR3, OR4; R2 = Me, Cl; R3 = H, C1-4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl, methylcyclopropyl; R4 = H, C1-4 alkyl) by reacting a compound of formula I (X = Br, Cl, I; R1 = NHR3, OR4; R2 = Me, Cl; R3 = H, C1-4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl, methylcyclopropyl; R4 = H, C1-4 alkyl) with at least one alkali metal cyanide in the presence of a nickel catalyst. Also disclosed is a method for preparing the nickel catalyst, by reacting 1-chloronaphthalene with dichlorobis(triphenylphosphine)nickel.. Furthermore, a method for removing nickel impurities from a mixture thereof with compounds of formula I (X = CN) comprising contacting the mixture with oxygen in the presence of an aqueous cyanide solution is disclosed. In addition, a method for preparing a compound of formula II (R2 = Me, Cl; R3 = H, C1-4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl, methylcyclopropyl; Z = CR8, N; R5 = Cl, Br, CF3, OCF2, OCH2CF3; R6 = F, Cl, Br; R7 = H, F, Cl; R8 = H, F, Cl, Br) using a compound of formula I, is disclosed. Example compound III was prepared by nickel-catalyzed cyanation of 2-amino-5-bromo-N,3-dimethylbenzamide; the resulting 2-amino-5-cyano-N,3-dimethylbenzamide underwent amidation with 3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid to give compound III. The experimental process involved the reaction of Methyl 2-amino-5-iodo-3-methylbenzoate(cas: 1096481-48-9).Formula: C9H10INO2

The Article related to halobenzoic acid derivative cyanation nickel, cyanobenzoic acid derivative preparation pyrazolecarboxylic acid amidation, cyanophenyl pyrazolecarboxamide preparation, nickel cyanation catalyst and other aspects.Formula: C9H10INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com