Category: 1048039-49-1

Tasch, Boris O. A. published the artcileOne-Pot Synthesis of Camalexins and 3,3′-Biindoles by the Masuda Borylation-Suzuki Arylation (MBSA) Sequence, Formula: C13H13ClINO2, the main research area is camalexin biindole Masuda borylation Suzuki arylation.

The Masuda borylation/Suzuki arylation (MBSA) sequence starting from N-protected 3-iodoindoles has successfully been extended to the coupling of five-membered heterocycles and indoles in the arylation step, which could not be achieved with previously developed MBSA methods. By this approach the one-pot nature of the method and the use of a simple catalyst system was retained. The applicability of the method was demonstrated by the facile synthesis of camalexins and 3,3′-biindoles, compounds of special interest due to their pronounced antifungal, antimicrobial and cytotoxic activities.

European Journal of Organic Chemistry published new progress about Arylation. 1048039-49-1 belongs to class iodides-buliding-blocks, name is tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate, and the molecular formula is C13H13ClINO2, Formula: C13H13ClINO2.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tasch, Boris O. A. published the artcileOne-Pot Synthesis of Diazine-Bridged Bisindoles and Concise Synthesis of the Marine Alkaloid Hyrtinadine A, Recommanded Product: tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate, the main research area is diazine bridged bisindole preparation borylation Suzuki arylation iodoindole iodoazaindole; hyrtinadine A synthesis antitumor agent.

Diazine-bridged bisindoles are readily obtained from N-Boc-protected 3-iodoindoles and 3-iodo-7-azaindole in a pseudo three-component reaction involving a one-pot Masuda borylation-Suzuki arylation sequence. Some of the title compounds display promising cytotoxic properties. The versatility of this methodol. is illustrated by a very concise total synthesis of the marine alkaloid hyrtinadine A (I).

European Journal of Organic Chemistry published new progress about Antitumor agents. 1048039-49-1 belongs to class iodides-buliding-blocks, name is tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate, and the molecular formula is C13H13ClINO2, Recommanded Product: tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mothes, Celine published the artcileAmino-zinc-ene-enolate cyclization: A short access to cis-3-substituted prolino-homotryptophane derivatives, Category: iodides-buliding-blocks, the main research area is proline substituted asym synthesis amino zinc enolate cyclization AZEE; prolinohomotryptophane chimera asym synthesis AZEE cyclization; enolate cyclization transmetalation iodination protection Negishi cross coupling indole.

Proline chimeras are useful tools for medicinal chem. and/or biol. applications. The asym. synthesis of cis-3-substituted prolines can be easily achieved via amino-zinc-ene-enolate cyclization followed by transmetalation of the cyclic zinc intermediate for further functionalization. Syntheses of prolino-homotryptophane derivatives were achieved through Negishi cross-coupling of the zinc intermediate with indole rings. The use of Pd catalyst derived from Fu’s [(t-Bu3)PH]-BF4 was required to avoid the undesired β-hydride elimination. Optically pure and orthogonally protected compounds were obtained readily usable for peptide synthesis.

Journal of Organic Chemistry published new progress about Cross-coupling reaction (Negishi). 1048039-49-1 belongs to class iodides-buliding-blocks, name is tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate, and the molecular formula is C13H13ClINO2, Category: iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sigala, Ioanna published the artcileLynamicin D an antimicrobial natural product affects splicing by inducing the expression of SR protein kinase 1, Safety of tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate, the main research area is lynamicin D bisindolyl bisindole pyrrole alkaloid mRNA splicing SRPK1; Bisindole pyrroles; Bisindolyl alkaloids; Lynamicin D; SRPK1; mRNA splicing.

The first total synthesis of the antimicrobial natural product lynamicin D has been developed using a Suzuki coupling to construct the bisindole pyrrole skeleton. An evaluation of the biol. activity of lynamicin D reveals that it has a minor effect on cell viability but it can modulate splicing of pre-mRNAs. We provide evidence that this effect is mainly due to the ability of lynamicin D to alter the levels of SRPK1, the key kinase involved in both constitutive and alternative splicing.

Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 1048039-49-1 belongs to class iodides-buliding-blocks, name is tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate, and the molecular formula is C13H13ClINO2, Safety of tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sigala, Ioanna published the artcileLynamicin D an antimicrobial natural product affects splicing by inducing the expression of SR protein kinase 1, Safety of tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate, the main research area is lynamicin D bisindolyl bisindole pyrrole alkaloid mRNA splicing SRPK1; Bisindole pyrroles; Bisindolyl alkaloids; Lynamicin D; SRPK1; mRNA splicing.

The first total synthesis of the antimicrobial natural product lynamicin D has been developed using a Suzuki coupling to construct the bisindole pyrrole skeleton. An evaluation of the biol. activity of lynamicin D reveals that it has a minor effect on cell viability but it can modulate splicing of pre-mRNAs. We provide evidence that this effect is mainly due to the ability of lynamicin D to alter the levels of SRPK1, the key kinase involved in both constitutive and alternative splicing.

Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 1048039-49-1 belongs to class iodides-buliding-blocks, name is tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate, and the molecular formula is C13H13ClINO2, Safety of tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com