Category: 104539-21-1

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 104539-21-1, name is 1-Iodo-2-(2-methoxyethoxy)ethane, This compound has unique chemical properties. The synthetic route is as follows., category: iodides-buliding-blocks

The 20 g of the above-mentioned synthesis of diethylene glycol monomethyl ether halogenated compounds and 10 ml 1 – methyl imidazole is added to the 50 ml flask, 80 C magnetic stirring reaction 60 h. After the reacting liquid to return to room temperature, ethyl acetate to fully wash, liquid orange viscous liquid obtained after, and in 120 C vacuum dried to obtain 1 – methyl -3 – diethylene glycol monomethyl ether imidazole iodide, is put into the glove box in standby.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 104539-21-1.

Reference:
Patent; Dalian Institute of Chemical Physics; Sun Gongquan; Yang Congrong; Wang Suli; (11 pag.)CN108218782; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 104539-21-1, A common heterocyclic compound, 104539-21-1, name is 1-Iodo-2-(2-methoxyethoxy)ethane, molecular formula is C5H11IO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

STR45 77 mg (0.158 mmol) of Compound 28 synthesised in Example 23 was dissolved in 2 ml of anhydrous DMF. To this solution, 255 mg (1.11 mmol) of 1-iodo-2-(2-methoxyethoxy)ethane and then 109 mg (0.79 mmol) of potassium carbonate were added. This reaction mixture was stirred in an atmosphere of argon at room temperature for 5 hours. The reaction mixture was then added to water. The mixture was then extracted with ethyl acetate. The extract layer was washed with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate, and concentrated. The residue was chromatographed on silica gel and eluted with a mixed solvent of ethyl acetate and hexane (2:1), whereby ethyl (E)-7-[6-(4′-fluorophenyl)-2,3-dihydro -7-[2-(2-methoxyethoxy) ethoxy ]-2,2-dimethyl -4-(propan-2-yl)benzo[b]furan-5-yl ]-3,5-dihydroxy-6-heptenoate (Compound 30) was obtained in a yield of 70 mg (75.3%). Melting point: 97.5~98.5 C. (colorless, fine particle-shaped crystals, recrystallized from a mixed solvent of ethyl acetate and hexane) 1 H-NMR (300MHz, CDCl3) delta 1.21 (d, J=7. 1Hz, 3H), 1.22 (d, J=7.1Hz, 3H), 1.28 (t, J=7.2Hz, 3H), 1.10-1.44 (m, 2H), 1.50 (s, 6H), 2.32-2.46 (m, 2H), 2.64-2.68 (m, 1H), 3.13 (s, 2H), 3.27 (hept, J=7.1Hz, 1H), 3.34 (s, 3H), 3.38 (s, 4H), 3.45-3.50 (m, 2H), 3.55-3.60 (m, 1H), 3.94-3.99 (m, 2H), 3.99-4.10 (m, 1H), 4.18 (q, J=7.2Hz, 2H), 4.20-4.31 (m, 1H), 5.09 (dd, J=16.0 and 6.6Hz, 1H), 6.33 (dd, J=16.0 and 1.0Hz, 1H), 6.94-7.04 (m, 2H), 7.08-7.16 (m, 2H)ppm. IR (KBr): 3432, 2972, 2936, 2880, 1722, 1596 cm-1. Mass (m/z, %): 588 (M+, 100), 570 (76), 454 (23), 413 (17), 311 (17), 269 (11), 103 (36), 59 (40).

The synthetic route of 104539-21-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fujirebio Inc.; US5523460; (1996); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 104539-21-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 104539-21-1 name is 1-Iodo-2-(2-methoxyethoxy)ethane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Individual solutions of N-(trimethylsilyl)methyl-N-benzylamine (15.5 mmol) in MeCN (100 mL) containing K2CO3 (31 mmol) and alkyl halide (30 mmol of 1-hexyl bromide, 2-(2-methoxyethoxy)ethyl iodide, ethyl 2-bromopropionate) were stirred for 12 h at room temperature and concentrated in vacuo to give residues that were triturated with CH2Cl2. The triturates were dried and concentrated in vacuo to afford residues, which were subjected to column chromatography (EtOAc: Hex=1: 8) to yield 19 (81 %), 22 (90 %) and 23 (44 %).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Iodo-2-(2-methoxyethoxy)ethane, and friends who are interested can also refer to it.

Reference:
Article; Lim, Suk Hyun; Cho, Dae Won; Mariano, Patrick S.; Tetrahedron; vol. 74; 3; (2018); p. 383 – 391;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 104539-21-1, name is 1-Iodo-2-(2-methoxyethoxy)ethane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 1-Iodo-2-(2-methoxyethoxy)ethane

Naphthalene-2,7-diol (1) (3.0 g, 19 mmol) was added to compound 2 (4.83 g, 21 mmol) in 30 mL of acetone with K2CO3 (3 g, 21 mmol). The reaction was stirred for 24 h, and the reaction mixture was extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate, concentrated, and purified by silica gel column chromatography (20% ethyl acetate in hexane) to afford compound 3 as a white solid, yield (4.0 g, 82%). 1H NMR (600 MHz, CDCl3): delta 7.65-7.59 (m, 2H), 7.01-6.90 (m, 4H), 5.46 (s, 1H), 4.19 (t, J = 4.83 Hz, 2H), 3.90 (t, J = 4.83 Hz, 2H), 3.79-0.374 (m, 2H), 3.64-3.60 (m, 2H), 3.42 (s, 3H) ppm; 13C NMR (150 MHz, CDCl3): delta 157.23, 154.36, 135.86, 129.30, 129.13, 124.17, 116.19, 115.56, 108.82, 105.48, 71.95, 70.63, 69.74, 67.12, 59.03 ppm; MS (ESI): 263 [M+H]+.

The synthetic route of 104539-21-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jeong, Jaemyeng; Kumar, Rangaraju Satish; Mergu, Naveen; Son, Young-A.; Journal of Molecular Structure; vol. 1147; (2017); p. 469 – 479;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 104539-21-1, name is 1-Iodo-2-(2-methoxyethoxy)ethane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 104539-21-1, name: 1-Iodo-2-(2-methoxyethoxy)ethane

STR27 100 mg (0.240 mmol) of Compound 5 synthesised in Reference Example 4 was dissolved in 1.0 ml of anhydrous DMF. To this solution, 166 mg (1.20 mmol) of potassium carbonate and a solution of 276 mg (1.20 mmol) of 1-iodo-2-(2-methoxyethoxy)ethane in 0.5 ml of anhydrous DMF were added. This reaction mixture was stirred at room temperature for 8 hours and 25 minutes. The reaction mixture was then added to a saturated aqueous solution of sodium chloride. The mixture was then extracted with ethyl acetate. The extract layer was washed with a saturated aqueous solution of sodium chloride two times, dried over magnesium sulfate, and concentrated. The residue was chromatographed on silica gel and eluted with a mixed solvent of ethyl acetate and hexane (1:1), whereby ethyl (E)-7-[4′-fluoro-5-[2-(2-methoxyethoxy)ethoxy]-3-(propan-2-yl)biphenyl-2-yl]-3,5-dihydroxy-6-heptenoate (Compound 11) was obtained in the form of a colorless oil in a yield of 26 mg (20.9%). 1 H-NMR (300 MHz, CDCl3) delta 1.18-1.33(m, 1H), 1.21(d, J=6.8 Hz, 3H), 1.22(d, J=6.8 Hz, 3H), 1.28(t, J=7.1 Hz, 3H), 1.38-1.53(m, 1H), 2.33-2.50(m, 2H), 2.84(d, J=2.0 Hz, 1H), 3.23(hept, J=6.8 Hz, 1H), 3.39(s, 3H), 3.52-3.64(m, 2H), 3.61(d, J=2.3 Hz, 1H), 3.68-3.76(m, 2H), 3.80-3.92(m, 2H), 4.02-4.22(m, 3H), 4.18(q, J=7.1 Hz, 2H), 4.22-4.40(m, 1H), 5.19(dd, J=16.0 and 6.4 Hz, 1H), 6.51(d, J=16.0 Hz, 1H), 6.65(d, J=2.7 Hz, 1H), 6.88(d, J=2.7 Hz, 1H), 6.96-7.06(m, 2H), 7.16-7.24 m, 2H)ppm. IR (liquid film): 3456, 2964, 2932, 1736, 1602, 1512cm-1. Mass (m/z, %): 518 (M+, 52), 500 (32), 454 (93), 369 (32), 267 (32), 241 (36), 239 (43), 230 (15), 183 (20), 103 (57), 59 (100).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-2-(2-methoxyethoxy)ethane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Fujirebio Inc.; US5393780; (1995); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com