Category: 1032231-24-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1032231-24-5, name is 2-Bromo-5-iodobenzaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2-Bromo-5-iodobenzaldehyde

Step 2: (2-bromo-5-iodophenyl)methanolTo a solution of 2-bromo-5-iodobenzaldehyde (12.4 g, 40 mmol) in MeOH (50 mL) was added NaBH4 (3 g, 80 mmol) at 0 C. After the addition, the reaction solution was stirred at rt for 30 minutes. The reaction solution was diluted with water (20 mL) and EtOAc (60 mL). The organic layer was separated and dried over anhydrous Na2S04. After removal of solvent, the residue was purified with column chromatography to afford (2-bromo-5- iodophenyl)methanol (3.5 g, 1 1 .2 mmol, 28 % yield) as a white solid.

According to the analysis of related databases, 1032231-24-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; JOHNS, Brian Alvin; SHOTWELL, John Brad; HAIGH, David; WO2012/67663; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 1032231-24-5, A common heterocyclic compound, 1032231-24-5, name is 2-Bromo-5-iodobenzaldehyde, molecular formula is C7H4BrIO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

According to the method described in a journal, European Journal of Organic Chemistry, 2008, No. 10, pp. 1797-1801, a compound represented by the formula (I-9-3) was produced. In a nitrogen atmosphere, 2.0 g of the compound represented by the formula (I-9-2), 3.0 g of the compound represented by the formula (I-9-3), 2.0 g of potassium carbonate, 20 mL of tetrahydrofuran, 20 mL of water, and 0.1 g of tetrakis(triphenylphosphine)palladium(0) were put in a reactor and heated with stirring. After ordinary post-treatment, this was purified through column chromatography to give 2.3 g of a compound represented by the formula (I-9-4).

The synthetic route of 1032231-24-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DIC Corporation; Horiguchi, Masahiro; Kadomoto, Yutaka; (139 pag.)US2018/22716; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 1032231-24-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1032231-24-5 name is 2-Bromo-5-iodobenzaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Diethylaminosulfur trifiuoride (77.8 g, 482 mmol) was added to a solution of 2-bromo- iodobenzaidehyde (100 g, 322 mmol) and DCM (1 L) at 0 C. The resultant mixture was stirred at room temperature for 2 h before quenching with ice/water (1 L) and extracting with DCM (800 mL x 3). The combined organic extracts were washed with brine, dried over anhydrous Na?S04, filtered and concentrated to dryness to give the crude product, which was purified by FCC on silica gel (PE/EtOAc = 50: 1) to afford the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-5-iodobenzaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; STEENECK, Christoph; GEGE, Christian; KINZEL, Olaf; KLEYMANN, Gerald; HOFFMANN, Thomas; GOLDBERG, Steven; (220 pag.)WO2016/69976; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com