Category: 10297-05-9

Synthesis of 2′-Substituted 4-Bromo-2,4′-bithiazoles by Regioselective Cross-Coupling Reactions was written by Bach, Thorsten;Heuser, Stefan. And the article was included in Journal of Organic Chemistry in 2002.Reference of 10297-05-9 This article mentions the following:

The synthesis of the title compounds [I; R = Bu, CH₂CHMe₂, CH₂CH₂Ph, (CH₂)₄Cl, CHMe₂, sec-Bu, Ph, CCCMe₃, CCPh, etc.] was achieved in two steps starting from readily available 2,4-dibromothiazole (II). In a regioselective Pd(0)-catalyzed cross-coupling step, II was converted to a variety of 2-substituted 4-bromothiazoles (III, same R) (10 examples, 65-85% yield). Alkyl and aryl zinc halides were employed as nucleophiles to introduce an alkyl or aryl substituent. The Sonogashira protocol was followed to achieve an alkynyl-debromination. Bromo-lithium exchange at C-4 and subsequent transmetalation to zinc or tin converted the 4-bromothiazoles to carbon nucleophiles, which underwent a second regioselective cross-coupling with another equivalent of 2,4-dibromothiazole. The Negishi cross-coupling gave high yields of the 2′-alkyl-4-bromo-2,4′-bithiazoles (88-97%). The synthesis of the 2′-phenyl- and 2′-alkynyl-4-bromo-2,4′-bithiazoles required a Stille cross-coupling that did not proceed as smoothly as the Negishi cross-coupling (58-62% yield). The title compounds, which were accessible in total yields of 38-82%, are versatile building blocks for the synthesis of 2,4′-bithiazoles. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Reference of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Reference of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nickel-catalyzed carbonylative synthesis of dihydrobenzofurans was written by Geng, Hui-Qing;Wang, Wei;Wu, Xiao-Feng. And the article was included in Catalysis Communications in 2021.Name: 1-Chloro-4-iodobutane This article mentions the following:

A nickel-catalyzed carbonylative synthesis of dihydrobenzofurans has been developed. With Mo(CO)6 as the CO source and manganese metal as the reductant, alkyl halides were reacted with aryl iodides to give the desired products in moderate to good yields. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Name: 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Name: 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Practical Asymmetric Synthesis of a Non-Peptidic α_vβ₃ Antagonist was written by Keen, Stephen P.;Cowden, Cameron J.;Bishop, Brian C.;Brands, Karel M. J.;Davies, Antony J.;Dolling, Ulf H.;Lieberman, David R.;Stewart, Gavin W.. And the article was included in Journal of Organic Chemistry in 2005.Reference of 10297-05-9 This article mentions the following:

The development of a practical and highly convergent synthesis of an α_vβ₃ antagonist I is described. The two key fragments present in this compound, a chiral 3-aryl-5-oxopentanoic acid II and a tetrahydropyrido[2,3-b]azepine ring system III (R= Boc), were constructed independently and then coupled at a late stage using a Wittig reaction. The pyridoazepine moiety was prepared from N-Boc 6-chloro-2-aminopyridine via directed ortho-metalation/alkylation followed by in situ cyclization. A Suzuki reaction was then used to attach the propionaldehyde side-chain required for Wittig coupling. The coupling partner was prepared from asym. methanolysis of a 3-substituted glutaric anhydride followed by elaboration of the acid moiety to the requisite β-keto phosphorane. Using this route, kilogram quantities of the desired drug candidate were prepared In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Reference of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Reference of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Double functionalization of N-Boc-3-(tosylmethyl)indole exploiting the activating properties of the tosyl group was written by Palmieri, Alessandro;Petrini, Marino;Shaikh, Rafik R.. And the article was included in Synlett in 2008.SDS of cas: 10297-05-9 This article mentions the following:

The anion prepared from N-Boc-3-(tosylmethyl)indole using NaH in DMF can be readily functionalized by reaction with various electrophiles. The obtained sulfonyl indoles, upon removal of the N-protecting group, undergo nucleophilic attack via a vinylogous imino derivative, leading to branched 3-substituted indoles. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9SDS of cas: 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.SDS of cas: 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ligand-Controlled Regiodivergent Hydroalkylation of Pyrrolines was written by Qian, Deyun;Hu, Xile. And the article was included in Angewandte Chemie, International Edition in 2019.Quality Control of 1-Chloro-4-iodobutane This article mentions the following:

Two series of C-alkylated pyrrolidines I [R = Boc, Cbz; R¹ = i-Pr, cyclopentyl, indol-1-yl, etc.] and II [R² = CO₂Ph, Boc, Cbz; R³ = cyclohexyl, (CH₂)₃Ph, 2-thienyl, etc.] were synthesized via ligand controlled nickel-catalyzed regiodivergent hydroalkylation of 3-pyrrolines with alkyl/aryl halides. This method demonstrated broad scope and high functional-group tolerance and could be applied in late-stage functionalizations. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Quality Control of 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Quality Control of 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Elucidation of the Structure of a Highly Active Catalytic System for CO₂/Epoxide Copolymerization: A salen-Cobaltate Complex of an Unusual Binding Mode was written by Na, Sung Jae;S, Sujith;Cyriac, Anish;Kim, Bo Eun;Yoo, Jina;Kang, Youn K.;Han, Su Jung;Lee, Chongmok;Lee, Bun Yeoul. And the article was included in Inorganic Chemistry in 2009.Name: 1-Chloro-4-iodobutane This article mentions the following:

Salen-type ligands comprised of ethylenediamine or 1,2-cyclohexenediamine, along with an salicylaldehyde bearing a Me substituent on its 3-position and a -[CR(CH₂CH₂CH₂N⁺Bu₃)₂] (R=H or Me) on its 5-position, unexpectedly afford cobalt(III) complexes with uncoordinated imines. In these complexes, two salen-phenoxys and two 2,4-dinitrophenolates (DNPs), which counter the quaternary ammonium cations, coordinate persistently with cobalt, while two other DNPs are fluxional between a coordinated and an uncoordinated state in THF at room temperature The complexes of this binding mode show excellent activities in carbon dioxide/propylene oxide copolymerization (TOF, 8 300-13 000 h^-1) but with some fluctuation in induction times (1-10 h), depending on how dry the system is. The induction time is shortened (<1.0 h) and activity is increased ∼1.5 times upon the replacement of the two fluxional DNPs with 2,4-dinitrophenol-2,4-dinitrophenolate homoconjugation ([DNP···H···DNP]^–). Imposing steric congestion either by replacing the Me substituent on the salicylaldehyde with tert-Bu or by employing H₂NCMe₂CMe₂NH₂ instead of ethylenediamine or 1,2-cyclohexenediamine results in conventional imine-coordinating complexes, which show lower activities than uncoordinated imine complexes. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Name: 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Name: 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Total synthesis of (±)-13-epineostenine was written by Tang, Meng;Fan, Chun-An;Zhang, Fu-Min;Tu, Yong-Qiang. And the article was included in Tetrahedron in 2009.Formula: C4H8ClI This article mentions the following:

An efficient total synthesis of (±)-13-epineostenine (I) has been achieved in 15 steps and 17% overall yield. This approach involved the key alkylation/Michael additions of the central 1,4-cyclohexanedione monoethylene acetal and all of the stereocenters on central cyclohexane moiety were generated in highly stereoselectivity. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Formula: C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Formula: C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Product class 1: organometallic complexes of zinc was written by Knochel, P.. And the article was included in Science of Synthesis in 2004.Application of 10297-05-9 This article mentions the following:

Preparation of zinc organometallic complexes are reviewed including sections on aryl, hetaryl, allenyl, allyl, alkynyl, alkenyl, alkyl and carbenoid complexes and triorganozincates. Applications of the complexes for organic syntheses are briefly given. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Application of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Application of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The Asymmetric Synthesis of Amines via Nickel-Catalyzed Enantioconvergent Substitution Reactions was written by Yang, Ze-Peng;Freas, Dylan J.;Fu, Gregory C.. And the article was included in Journal of the American Chemical Society in 2021.Recommanded Product: 1-Chloro-4-iodobutane This article mentions the following:

Herein, two mild methods was reported for the catalytic enantioconvergent synthesis of protected dialkyl carbinamines such as RCHXR¹ [R = i-Bu, n-hexyl, (CH₂)₅F, etc.; R¹ = Et, i-Bu, (CH₂)₂Ph, etc.; X = NHBoc, Phth, NHFmoc, etc.], both of which use a chiral nickel catalyst to couple an alkylzinc reagent with α-phthalimido alkyl chloride or an N-hydroxyphthalimide (NHP) ester of a protected α-amino acid. The methods were versatile, providing dialkyl carbinamine derivatives that bear an array of functional groups. Further, for couplings of NHP esters a one-pot variant wherein the NHP ester was generated in situ, allowing the generation of enantioenriched protected dialkyl carbinamines in one step from com. available amino acid derivatives was also described. The utility of this method by applying it to the efficient catalytic enantioselective synthesis of a range of interesting target mols. was demonstrated. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Recommanded Product: 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Recommanded Product: 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rapid Access to Aliphatic Sulfonamides was written by Zhang, Mingjun;Yu, Mo;Wang, Ziwen;Liu, Yuxiu;Wang, Qingmin. And the article was included in Organic Letters in 2022.Computed Properties of C4H8ClI This article mentions the following:

Herein, a mild, rapid, straightforward method for visible-light-mediated sulfonamide ethylation to afford a diverse array of compounds with C(sp³)-sulfonamide skeletons RS(O)₂N(R¹)R² (R = 4-phenylbutyl, 3,3-dimethylbutyl, 2-cyclobutylethyl, 4-(pyridin-2-yl)butyl, etc.; R¹ = H, Ph, 2-oxooxolan-3-yl, benzyl, etc.; R² = H, Me, phenyl) was reported. The method relies on inexpensive, abundant, com. available primary, secondary, and tertiary alkyl carboxylic acids I (R³ = 2-phenylethyl, 2,2-diphenylethyl, 2-(pyridin-3-yl)ethyl, pentyl, etc.) and alkyl iodides R⁴I (R⁴ = 2-cyclohexylethyl, pentyl, 4-(trimethylsilyl)butyl, hept-6-yn-1-yl, etc.) as substrates. The method has a broad substrate scope and potential utility for late-stage functionalization of natural products and synthetic medicines and can be expected to facilitate rapid structural diversification of bioactive mols. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Computed Properties of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Computed Properties of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com