Category: 10297-05-9

Synthesis and SAR investigations of novel 2-arylbenzimidazole derivatives as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists was written by Lim, Chae Jo;Kim, Nakjeong;Lee, Eun Kyoung;Lee, Byung Ho;Oh, Kwang-Seok;Yoo, Sung-eun;Yi, Kyu Yang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Electric Literature of C4H8ClI This article mentions the following:

Compounds containing 2-arybenzimidazole ring systems linked to arylpiperidines were synthesized and evaluated as MCH-R1 antagonists. The results of structure-activity relationship studies led to the identification of compound I as a potent MCH-R1 antagonist (IC₅₀ = 1 nM). This compound also has good metabolic stability, and favorable pharmacokinetic and brain penetration properties. However I was found to be potent inhibitor of the hERG potassium channel. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Electric Literature of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Electric Literature of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Substituted carborane-appended water-soluble single-wall carbon nanotubes: new approach to boron neutron capture therapy drug delivery was written by Yinghuai, Zhu;Peng, Ang Thiam;Carpenter, Keith;Maguire, John A.;Hosmane, Narayan S.;Takagaki, Masao. And the article was included in Journal of the American Chemical Society in 2005.Name: 1-Chloro-4-iodobutane This article mentions the following:

Substituted C₂B₁₀ carborane cages have been successfully attached to the side walls of single-wall carbon nanotubes (SWCNTs) via nitrene cycloaddition The decapitations of these C₂B₁₀ carborane cages, with the appended SWCNTs intact, were accomplished by the reaction with sodium hydroxide in refluxing ethanol. During base reflux, the three-membered ring formed by the nitrene and SWCNT was opened to produce water-soluble SWCNTs in which the side walls are functionalized by both substituted nido-C₂B₉ carborane units and ethoxide moieties. All new compounds were characterized by EA, SEM, TEM, UV, NMR, and IR spectra and chem. analyses. Selected tissue distribution studies on one of these nanotubes, {([Na⁺][1-Me-2-((CH₂)₄NH-)-1,2-C₂B₉H₁₀][OEt])_n(SWCNT)} (Va), showed that the boron atoms are concentrated more in tumors cells than in blood and other organs, making it an attractive nanovehicle for the delivery of boron to tumor cells for an effective boron neutron capture therapy in the treatment of cancer. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Name: 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Name: 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Diamine derivatives containing imidazolidinylidenepropanedinitrile as a new class of histamine H₃ receptor antagonists. Part I was written by Sasho, Setsuya;Seishi, Takashi;Kawamura, Mariko;Hirose, Ryo;Toki, Shinichiro;Shimada, Jun-ich. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Safety of 1-Chloro-4-iodobutane This article mentions the following:

Title compounds (I) were synthesized and evaluated for histamine H₃ receptor-binding affinities. I [R = piperidino, n = 4; R = 2-methylpyrroldiino (Q), (S)-Q, n = 3] showed potent H₃ receptor antagonism and excellent selectivity over human H₁, H₂ and H₄ receptors. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Safety of 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons鑱砈mith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Safety of 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mn-Mediated Coupling of Alkyl Iodides and Chiral N-Acylhydrazones: Optimization, Scope, and Evidence for a Radical Mechanism was written by Friestad, Gregory K.;Marie, Jean-Charles;Suh, YoungSung;Qin, Jun. And the article was included in Journal of Organic Chemistry in 2006.Product Details of 10297-05-9 This article mentions the following:

Stereoselective radical additions have excellent potential as mild, nonbasic carbon-carbon bond constructions for direct asym. amine synthesis. Efficient intermol. radical addition to C:N bonds with acyclic stereocontrol has previously been limited mainly to secondary and tertiary radicals, a serious limitation from the perspective of synthetic applications. Here, we provide full details of the use of photolysis with manganese carbonyl to mediate stereoselective intermol. radical addition to N-acylhydrazones. Photolysis (300 nm) of alkyl halides and hydrazones in the presence of Mn₂(CO)₁₀ and InCl₃ as a Lewis acid led to reductive radical addition; diastereomer ratios ranged from 93:7 to 98:2 at ca. 35 鎺矯. The reaction tolerates addnl. functionality in either reactant, enabling subsequent transformations as shown in an efficient asym. synthesis of coniine. A series of hydrazones bearing different substituents on the oxazolidinone auxiliary were compared; consistently high diastereoselectivity revealed that the identity of the substituent had little practical effect on the diastereoselectivity. Further mechanistic control experiments confirmed the intermediacy of radicals and showed that independently prepared alkyl- or acyl manganese pentacarbonyl compounds do not undergo efficient addition to the N-acylhydrazones under thermal or photolytic (300 nm) conditions. These Mn-mediated conditions avoid toxic tin reagents and enable stereoselective intermol. radical additions to C:N bonds with the broadest range of alkyl halides yet reported, including previously ineffective primary alkyl halides. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Product Details of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Product Details of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Photoredox relay-catalyzed gem-difluoroallylation of alkyl iodides was written by Guo, Yuanqiang;Cao, Yunpeng;Song, Hongjian;Liu, Yuxiu;Wang, Qingmin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.SDS of cas: 10297-05-9 This article mentions the following:

Herein, a new example of relay catalysis, using a combination of Mn₂(CO)₁₀ and an iridium-based photocatalyst, is reported. In this relay catalytic reaction, the Mn catalyst and iridium-based photocatalyst catalyze the reaction at different stages in the desired sequence under the same reaction conditions, and do not inhibit each other. This convenient method transforms a broad scope of alkyl iodides RI (R = iso-Pr, cyclopentyl, 4-methoxyphenethyl, morpholino, etc.) into the corresponding gem-difluoroalkenes R¹C(=CF₂)CH₂R (R¹ = Ph, 2-naphthyl, pyridin-3-yl, etc.) via C(sp³)-C(sp³) bond construction. The protocol has good functional group tolerance and is suitable for the late-stage modification of multifunctional complex mols. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9SDS of cas: 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.SDS of cas: 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Alkenenitriles: Conjugate Additions of Alkyl Iodides with a Silica-Supported Zinc-Copper Matrix in Water was written by Fleming, Fraser F.;Gudipati, Subrahmanyam;Aitken, Jennifer A.. And the article was included in Journal of Organic Chemistry in 2007.Synthetic Route of C4H8ClI This article mentions the following:

A new silica-supported zinc-copper matrix reagent promotes the conjugate addition of alkyl iodides to cyclic and acyclic alkenenitriles in water. X-ray diffraction and electron microscopy techniques suggest that the active copper species generated from elemental zinc and copper(I) iodide is finely dispersed, zerovalent copper. Alkyl iodides react with the silica-supported reagent to generate putative radicaloid intermediates that efficiently add to alkenenitriles to provide 灏?substituted nitriles. Conjugate additions to acyclic and cyclic 5-7-membered alkenenitriles are most effective for primary alkyl iodides, although secondary and tertiary alkyl iodides are viable reaction partners. The strategy addresses the challenge of performing conjugate additions to disubstituted alkenenitriles and demonstrates the beneficial role of the silica-supported reagent. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Synthetic Route of C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Synthetic Route of C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Preparation, Structure, and Reactivity of Nonstabilized Organoiron Compounds. Implications for Iron-Catalyzed Cross Coupling Reactions was written by Fuerstner, Alois;Martin, Ruben;Krause, Helga;Seidel, Gunter;Goddard, Richard;Lehmann, Christian W.. And the article was included in Journal of the American Chemical Society in 2008.Recommanded Product: 1-Chloro-4-iodobutane This article mentions the following:

A series of unprecedented organoiron complexes of the formal oxidation states -2, 0, +1, +2, and +3 is presented, which are largely devoid of stabilizing ligands and, in part, also electronically unsaturated (14-, 16-, 17- and 18-electron counts). Specifically, it is shown that nucleophiles unable to undergo 灏?hydride elimination, such as MeLi, PhLi, or PhMgBr, rapidly reduce Fe(3+) to Fe(2+) and then exhaustively alkylate the metal center. The resulting homoleptic organoferrate complexes [(Me₄Fe)(MeLi)][Li(OEt₂)]₂ (3) and [Ph₄Fe][Li(Et₂O)₂][Li(1,4-dioxane)] (5) could be characterized by x-ray crystal structure anal. However, these exceptionally sensitive compounds turned out to be only moderately nucleophilic, transferring their organic ligands to activated electrophiles only, while being unable to alkylate (hetero)aryl halides unless they are very electron deficient. In striking contrast, Grignard reagents bearing alkyl residues amenable to 灏?hydride elimination reduce FeX_n (n = 2, 3) to clusters of the formal composition [Fe(MgX)₂]_n. The behavior of these intermetallic species can be emulated by structurally well-defined lithium ferrate complexes of the type [Fe(C₂H₄)₄][Li(tmeda)]₂ (8), [Fe(cod)₂][Li(dme)]₂ (9), [CpFe(C₂H₄)₂][Li(tmeda)] (7), [CpFe(cod)][Li(dme)] (11), or [Cp^*Fe(C₂H₄)₂][Li(tmeda)] (14). Such electron-rich complexes, which are distinguished by short intermetallic Fe-Li bonds, were shown to react with aryl chlorides and allyl halides; the structures and reactivity patterns of the resulting organoiron compounds provide first insights into the elementary steps of low valent iron-catalyzed cross coupling reactions of aryl, alkyl, allyl, benzyl, and propargyl halides with organomagnesium reagents. However, the acquired data suggest that such C-C bond formations can occur, a priori, along different catalytic cycles shuttling between metal centers of the formal oxidation states Fe(+1)/Fe(+3), Fe(0)/Fe(+2), and Fe(-2)/Fe(0). Since these different manifolds are likely interconnected, an unambiguous decision as to which redox cycle dominates in solution remains difficult, even though iron complexes of the lowest accessible formal oxidation states promote the reactions most effectively. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Recommanded Product: 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C閳ユ彂 bond. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Recommanded Product: 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nickel-Catalyzed Cross-Coupling between Functionalized Primary or Secondary Alkylzinc Halides and Primary Alkyl Halides was written by Jensen, Anne Eeg;Knochel, Paul. And the article was included in Journal of Organic Chemistry in 2002.COA of Formula: C4H8ClI This article mentions the following:

In the presence of Bu₄NI (3 equiv) and 4-fluorostyrene (20 mol %), unreactive primary and secondary alkylzinc iodides undergo nickel-catalyzed cross-couplings with various primary alkyl iodides or bromides. More reactive secondary dialkylzincs and the mixed zinc organometallics RZnTMSM undergo the cross-coupling reaction in the absence of Bu₄NI. The bicyclic secondary diorganozinc prepared via boron-zinc exchange reacts with high retention of configuration. Free NH-groups are tolerated in the cross-coupling allowing the synthesis of aminated products. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9COA of Formula: C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C閳ユ彂 bond. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.COA of Formula: C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthesis of 2′-Substituted 4-Bromo-2,4′-bithiazoles by Regioselective Cross-Coupling Reactions was written by Bach, Thorsten;Heuser, Stefan. And the article was included in Journal of Organic Chemistry in 2002.Reference of 10297-05-9 This article mentions the following:

The synthesis of the title compounds [I; R = Bu, CH₂CHMe₂, CH₂CH₂Ph, (CH₂)₄Cl, CHMe₂, sec-Bu, Ph, C椤氬挵CMe₃, C椤氬挵Ph, etc.] was achieved in two steps starting from readily available 2,4-dibromothiazole (II). In a regioselective Pd(0)-catalyzed cross-coupling step, II was converted to a variety of 2-substituted 4-bromothiazoles (III, same R) (10 examples, 65-85% yield). Alkyl and aryl zinc halides were employed as nucleophiles to introduce an alkyl or aryl substituent. The Sonogashira protocol was followed to achieve an alkynyl-debromination. Bromo-lithium exchange at C-4 and subsequent transmetalation to zinc or tin converted the 4-bromothiazoles to carbon nucleophiles, which underwent a second regioselective cross-coupling with another equivalent of 2,4-dibromothiazole. The Negishi cross-coupling gave high yields of the 2′-alkyl-4-bromo-2,4′-bithiazoles (88-97%). The synthesis of the 2′-phenyl- and 2′-alkynyl-4-bromo-2,4′-bithiazoles required a Stille cross-coupling that did not proceed as smoothly as the Negishi cross-coupling (58-62% yield). The title compounds, which were accessible in total yields of 38-82%, are versatile building blocks for the synthesis of 2,4′-bithiazoles. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Reference of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Reference of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nickel-Catalyzed Cross-Coupling between Functionalized Primary or Secondary Alkylzinc Halides and Primary Alkyl Halides was written by Jensen, Anne Eeg;Knochel, Paul. And the article was included in Journal of Organic Chemistry in 2002.COA of Formula: C4H8ClI This article mentions the following:

In the presence of Bu₄NI (3 equiv) and 4-fluorostyrene (20 mol %), unreactive primary and secondary alkylzinc iodides undergo nickel-catalyzed cross-couplings with various primary alkyl iodides or bromides. More reactive secondary dialkylzincs and the mixed zinc organometallics RZnTMSM undergo the cross-coupling reaction in the absence of Bu₄NI. The bicyclic secondary diorganozinc prepared via boron-zinc exchange reacts with high retention of configuration. Free NH-groups are tolerated in the cross-coupling allowing the synthesis of aminated products. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9COA of Formula: C4H8ClI).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.COA of Formula: C4H8ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com