Category: 1022128-96-6

Adding a certain compound to certain chemical reactions, such as: 1022128-96-6, name is 2-Bromo-6-iodobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1022128-96-6, COA of Formula: C7H4BrIO2

9.1 (7.32 g, 22 mmol) was dissolved in 40 mL of tetrahydrofuran, 4 mL of thionyl chloride and a catalytic amount of N,N-dimethylformamide After reacting for 3 hours, the reaction solution was spun off, and the residue was added with 40 mL of tetrahydrofuran, and ammonia was added dropwise with stirring in an ice bath. 33 mL of water was allowed to stand at room temperature for 3 hours. Extract with ethyl acetate and wash with saturated sodium bicarbonate. The organic layer is dry and concentrated. With a small amount of dichloromethane and purified by recrystallization from n-hexane to give a large number of white solid 9.2 6.09g, the yield was 85%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-6-iodobenzoic acid, and friends who are interested can also refer to it.

Reference:
Patent; East China University of Science and Technology; Wang Wei; Chen Xiaobei; Shen Zuyuan; Qian Pengfei; Geng Huihui; (24 pag.)CN109942505; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 1022128-96-6, A common heterocyclic compound, 1022128-96-6, name is 2-Bromo-6-iodobenzoic acid, molecular formula is C7H4BrIO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of ortho-diiodobenzoic acid derivative (2.67 mmol,1.0 equiv.), NIS (2.0 equiv.), and 1,2-dichloroethane (DCE; 10 mL) were added to a flame-dried 100 mL round-bottom flask, and the mixture was irradiated with 100 W (tungsten lamp) under reflux conditions for 24 h. The reaction mixture was then cooled to room temperature. The mixture was then washed withsaturated NaHSO3, saturated NaHCO3, and brine. The organic layers were collected and then dried over anhydrous Na2SO4, filtered, and concentrated in a rotary evaporator. The residue was then purified by flash chromatography on silica gel (100% hexane) to give the desired iodinated product.

The synthetic route of 1022128-96-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Al-Zoubi, Raed M.; Al-Mughaid, Hussein; McDonald, Robert; Australian Journal of Chemistry; vol. 68; 6; (2015); p. 912 – 918;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com