Category: 1020174-06-4

Palladium-Catalyzed Asymmetric Intramolecular Reductive Heck Desymmetrization of Cyclopentenes: Access to Chiral Bicyclo[3.2.1]octanes was written by Yuan, Zhenbo;Feng, Ziwen;Zeng, Yuye;Zhao, Xiaobin;Lin, Aijun;Yao, Hequan. And the article was included in Angewandte Chemie, International Edition in 2019.Category: iodides-buliding-blocks The following contents are mentioned in the article:

A palladium-catalyzed asym. reductive Heck reaction of unactivated aliphatic alkenes, with eliminable β-hydrogen atoms, was realized for the first time. A series of optically active bicyclo[3.2.1]octanes bearing chiral quaternary and tertiary carbon stereocenters were obtained in good yields with excellent enantioselectivities, exhibited good functional-group tolerance and scalability. Moreover, deuterated optically active bicyclo[3.2.1]octanes were also obtained in high efficiency. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4Category: iodides-buliding-blocks).

Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

An efficient and mild ortho-zincation of aromatics and heterocycles by using TMP₂Mg·2LiCl in the presence of ZnCl₂ was written by Dong, Zhi-Bing;Zhu, Wei-Hua;Zhang, Zhi-Guang;Li, Min-Zhi. And the article was included in Journal of Organometallic Chemistry in 2010.COA of Formula: C9H8ClIO2 The following contents are mentioned in the article:

A variety range of functionalized aryl and heteroaryl zinc reagents were efficiently generated by using TMP₂Mg·2LiCl (TMP = 2,2,6,6-tetramethylpiperidinyl) in the presence of ZnCl₂. The subsequently functionalization gave after reaction with electrophiles the expected polyfunctionalized products in good yields. E.g., metalation of pyrazine with ZnCl₂, followed by TMP₂Mg·2LiCl, then treatment with I₂, gave 71% 2-iodopyrazine. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4COA of Formula: C9H8ClIO2).

Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.COA of Formula: C9H8ClIO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

One-Pot C-H Arylation/Lactamization Cascade Reaction of Free Benzylamines was written by Chand-Thakuri, Pratibha;Landge, Vinod G.;Kapoor, Mohit;Young, Michael C.. And the article was included in Journal of Organic Chemistry in 2020.Electric Literature of C9H8ClIO2 The following contents are mentioned in the article:

An efficient method was developed for the synthesis of seven-membered biaryl lactams I [R¹ = H, 8-F, 9-OMe, etc.; R² = R³ = H, Me; R² = H, R³ = Me; R² = Me, R³ = Et, n-Pr, n-Bu, etc.; R⁴ = H, 2-Cl, 3-I, etc.] involving Pd-catalyzed, native amine-directed, ortho-arylation of benzylamines followed by in situ lactamization. This cascade sequence was enabled by the use of 2-iodobenzoates, which facilitated C-H arylation from the free amine under conditions that typically required an improved directing group approach. This reaction was characterized by a broad substrate scope with good functional group tolerance. The need for an ester vs. carboxylic acid-functionalized coupling partner was also explored, as the potential for synthesizing eight-membered biaryl lactams. Various applications were also investigated, including access to the aza-Brassinolide core. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4Electric Literature of C9H8ClIO2).

Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Electric Literature of C9H8ClIO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Critical Ligand and Salt Effects in Organomagnesiate-Promoted 3,3-Disubstituted Phthalides Synthesis from 2-Iodobenzoate Derivatives was written by Touchet, Sabrina;Yeardley, Callum;O’Hara, Charles T.;Gros, Philippe C.. And the article was included in European Journal of Organic Chemistry in 2021.Formula: C9H8ClIO2 The following contents are mentioned in the article:

A convergent route using a metal halogen exchange (MHE) strategy was reported. Indeed MHE of easily available 2-iodobenzoate derivatives, using the bimetallic organomagnesiate complex (rac)-(BIPHEN)BuMgLi, where (rac)-BIPHEN is (rac)-5,5′,6,6′-tetramethyl-3,3′-di-t-butyl-1,1′-biphenyl-2,2′-diol, followed by addition of a ketone which led to an intramol. cyclization and the formation of a series of diverse 3,3-disubstituted isobenzofuranones in good yield. Among the several MHE agents investigated, (rac)-(BIPHEN)BuMgLi was the only one to make such a process possible with full tolerance of various reactive functional substituents useful for subsequent transformations. The synthetic pathway to access the magnesiate was found to play a prominent role in its reactivity. Therefore, the bimetallic magnesiate complex was characterized by solution-state ¹H, ⁷Li and ¹H DOSY NMR experiments This study involved multiple reactions and reactants, such as Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4Formula: C9H8ClIO2).

Ethyl 4-chloro-2-iodobenzoate (cas: 1020174-06-4) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Formula: C9H8ClIO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com