101066-87-9 Archives - Iodides-buliding-blocks

15-Sep-21 News Share a compound : 101066-87-9

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-2-(trifluoromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Application of 101066-87-9, The chemical industry reduces the impact on the environment during synthesis 101066-87-9, name is 4-Iodo-2-(trifluoromethyl)benzonitrile, I believe this compound will play a more active role in future production and life.

Step C. 4-(lH-pyrazol-4-yl)-2-(trifluoromethyl)benzonitrile A mixture of 4-(4,4,5,5-tetramethyl-l ,3,2-dioxaborolan-2-yl)-lH-pyrazole (CAS: 269410- 08-4, Sigma- Aldrich) (300 mg, 1.55 mmol), 4-iodo-2-(trifluoromethyl)benzonitrile (300 mg, 1.01 mmol), Pd(PPh3)4 (18.6 mg, 0.016 mmol), K2C03 (891 mg, 6.46 mmol), and water (2 mL) in 1 ,4-dioxane (10 mL) under nitrogen was heated at 90 C overnight. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel chromatography using petroleum ether :EtO Ac (1 : 1) as eluting solvents to afford 4-(lH-pyrazol-4-yl)-2-(trifluoromethyl)benzonitrile as a white solid (203 mg, 84%). LCMS (ESI) m/z: 238.1 [M+H]+.

Reference:
Patent; BEAUFOUR-IPSEN (TIANJIN) PHARMACEUTICAL CO., LTD.; AUVIN, Serge; LANCO, Christophe; DUTRUEL, Oliver; CHAO, Qi; GU, Kaichun; WO2015/100617; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some scientific research about 101066-87-9

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Adding a certain compound to certain chemical reactions, such as: 101066-87-9, name is 4-Iodo-2-(trifluoromethyl)benzonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 101066-87-9, SDS of cas: 101066-87-9

. Step D. tert-butyl 3-(4-cvano-3-(trifluoromethyl)phenyl)pyrrolidine-l-carboxylate A suspension of tert-butyl 4-(4-cyano-3-(trifluoromethyl)phenyl)-2,3-dihydro-lH-pyrrole- 1-carboxylate and tert-butyl 3-(4-cyano-3-(trifluoromethyl)phenyl)-2,5-dihydro-lH- pyrrole-l-carboxylate (370 mg, 1.10 mmol) and Pd/C (100 mg) in THF (8 mL) was stirred under hydrogen at room temperature for 2 hours. The reaction mixture was filtered and the filtrate was concentrated to afford tert-butyl 3-(4-cyano-3- (trifluoromethyl)phenyl)pyrrolidine-l-carboxylate as a white powder (350 mg, 94%), which was used for the next step without further purification. LCMS (ESI) m/z: 285.1 [M- 56+H]+.

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The important role of C8H3F3IN

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 101066-87-9, name is 4-Iodo-2-(trifluoromethyl)benzonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Iodo-2-(trifluoromethyl)benzonitrile

Step A. tert-butyl 3-(4-cvano-3-(trifluoromethyl)phenyl)-3-hvdroxypyrrolidine-l- carboxylate To a mixture of 4-iodo-2-(trifluoromethyl)benzonitrile (946 mg, 2.702 mmol) in THF (5 mL) at 0 C was added a solution of BuLi in hexane (1.29 mL, 3.25 mmol) and stirred under nitrogen for 1 hour. To the mixture at 0 C was added a solution of tert-butyl 3- oxopyrrolidine-l-carboxylate (500 mg, 2.702 mmol) in THF (5 mL) and stirred at room temperature for 4 hours. The reaction mixture was quenched with H20 (20 mL) and extracted with ethyl acetate (20 mL x 2). The extracts were combined, washed with brine (20 mL), dried over sodium sulfate, filtered, and concentrated under reduced pressure to afford tert-butyl 3 -(4-cyano-3 -(trifluoromethyl)phenyl)-3 -hydroxypyrrolidine- 1 – carboxylate as a white solid (368 mg, 38%). LCMS (ESI) m/z: 301.0 [M-56+H]+.

Introduction of a new synthetic route about 101066-87-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Iodo-2-(trifluoromethyl)benzonitrile, and friends who are interested can also refer to it.

Application of 101066-87-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 101066-87-9 name is 4-Iodo-2-(trifluoromethyl)benzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Under N2 atmosphere, a mixture of intermediate 12 (263.5 mg,1.0 mmol), 3-bromoaniline (172.0 mg, 1.0 mmol), Cs2CO3 (325.8 mg,1.0 mmol), Pd2(dba)3 (45.8 mg, 0.05 mmol) and Davephos (31.5 mg,0.08 mmol) in MeCN (6.0 ml) was heated to reflux for 5 h. The reactionmixture was cooled to room temperature and diluted withethyl acetate. The resulting mixturewas filtered off and the solutionwas concentrated under vacuum to give a crude product 16 thatwas purified by column chromatography on silica using a solvent of10% ethyl acetate in hexanes. The desired compound 16 was obtainedas a yellow solid (220.0 mg, yield 72%). For the synthesis ofintermediate 13-15, compound 12 or commercially available 11and corresponding aromatic amine were used respectivelyfollowing the procedure described for 16.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Iodo-2-(trifluoromethyl)benzonitrile, and friends who are interested can also refer to it.

Reference:
Article; Yu, Jiang; Zhang, Lanxi; Yan, Guoyi; Zhou, Peiting; Cao, Chaoguo; Zhou, Fei; Li, Xinghai; Chen, Yuanwei; European Journal of Medicinal Chemistry; vol. 171; (2019); p. 265 – 281;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The important role of C8H3F3IN

The chemical industry reduces the impact on the environment during synthesis 4-Iodo-2-(trifluoromethyl)benzonitrile. I believe this compound will play a more active role in future production and life.

Electric Literature of 101066-87-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 101066-87-9, name is 4-Iodo-2-(trifluoromethyl)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Example 18 A mixture of 4-iodo-2-trifluoromethylbenzonitrile (1.65 g.), bis-(triphenylphosphine)palladium (II) chloride (0.07 g.), cuprous iodide (0.01 g.), 1-methylsulphonyl-2-trifluoromethylbut-3-yn-2-ol (1.2 g.) and diethylamine (25 ml.) was stirred at laboratory temperature under an atmosphere of argon for 4 hours and then evaporated to dryness. The residue was purified by flash chromatography on a silica gel (Merck 9385) column using a 1:1 v/v mixture of ethyl acetate and petroleum ether (b.p. 60-80C.) as eluant, and the product was crystallized from a 4:1 v/v mixture of petroleum ether (b.p. 60-80C.) and ethyl acetate. There was thus obtained 4-(4-cyano-3-trifluoromethylphenyl)-1-methylsulphonyl-2-trifluoromethylbut-3-yn-2-ol, m.p. 134-136C.

Reference:
Patent; IMPERIAL CHEMICAL INDUSTRIES PLC; EP154528; (1991); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Extended knowledge of 101066-87-9

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 101066-87-9.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 101066-87-9, name is 4-Iodo-2-(trifluoromethyl)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-Iodo-2-(trifluoromethyl)benzonitrile

A suspension of frans-1-(4-methoxybenzyl)hexahydropyrano [3,4-cfl imidazol-2(3/-/)-one [racemic (±)] (0.25 g, 0.95 mmol), 4-iodo-2-(trifluoromethyl)benzonitrile (0.28 g, 0.95 mmol), frans-A/,A/’-dimethylcyclohexane-1 ,2-diamine (0.032 g, 0.29 mmol) and potassium carbonate (0.395 g, 2.86 mmol) in toluene (15 ml_) was degassed for 30 min in a microwave vial. Cul (0.009 g, 0.05 mmol) was added and the vial was sealed with an aluminum cap. The sealed vial was kept in a preheated oil bath at 1 10 C and stirred for 12 h. The reaction mixture was cooled to RT, filtered through a pad of celite, and filtrates were concentrated under reduced pressure to give a black residue. The residue was purified by column chromatography on silica gel (dichloromethane/methanol = 100:0 to 99: 1 ) to give the title compound (0.17 g, 41.0%) as an off white solid. LCMS: m/z 432.1 [M+H]+; H NMR (400 MHz, CDCI3) delta 7.80-7.74 (m, 2H), 7.54 (d, 1 H), 7.20 (d, 2H), 6.84 (d, 2H), 4.50 (d, 1 H), 4.40-4.30 (m, 2H), 4.15-4.05 (m, 1 H), 3.80 (s, 3H), 3.65 (ddd, 1 H), 3.50-3.20 (m, 2H), 3.10 (ddd, 1 H), 1.90 (d, 1 H), 1 .72-1.68 (m, 1 H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 101066-87-9.

Reference:
Patent; NOVARTIS AG; BOCK, Mark; CHIKKANNA, Dinesh; GERSPACHER, Marc; KHAIRNAR, Vinayak; LAGU, Bharat; PANDIT, Chetan; WO2013/84138; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Simple exploration of C8H3F3IN

The synthetic route of 101066-87-9 has been constantly updated, and we look forward to future research findings.

Reference of 101066-87-9, These common heterocyclic compound, 101066-87-9, name is 4-Iodo-2-(trifluoromethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 4c (6.0 g, 24.7 mmol), 4-iodo-2-(trifluoromethyl)benzonitrile (8.42 g, 28.4 mmol), Xantphos (2.14 g, 3.70 mmol),Pd2(dba)3 (1.13 g, 1.23 mmol) and Cs2CO3 (12.05 g, 36.98 mmol)in toluene (70 ml) was stirred at 80 C for 18 h, and the resultingmixture was partitioned between water and ethylacetate. Theorganic layer was dried over MgSO4, and concentrated in vacuo.The residue was purified by silica gel column chromatography(n-hexane:EtOAc = 50:1 to 1:2) to afford 4-((2S,3S)-3-{[tert-Butyl(dimethyl)silyl]oxy}-2-ethyl-5-oxopyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile

The synthetic route of 101066-87-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Aikawa, Katsuji; Asano, Moriteru; Ono, Koji; Habuka, Noriyuki; Yano, Jason; Wilson, Keith; Fujita, Hisashi; Kandori, Hitoshi; Hara, Takahito; Morimoto, Megumi; Santou, Takashi; Yamaoka, Masuo; Nakayama, Masaharu; Hasuoka, Atsushi; Bioorganic and Medicinal Chemistry; vol. 25; 13; (2017); p. 3330 – 3349;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sources of common compounds: 101066-87-9

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EXAMPLE 18 A mixture of 4-iodo-2-trifluoromethylbenzonitrile (1.65 g.), bis-(triphenylphosphine)palladium (II) chloride (0.07 g.), cuprous iodide (0.01 g.), 1-methylsulphonyl-2-trifluoromethylbut-3-yn-2-ol (1.2 g.) and diethylamine (25 ml.) was stirred at laboratory temperature under an atmosphere of argon for 4 hours and then evaporated to dryness. The residue was purified by flash chromatography on a silica gel (Merck 385) column using a 1:1 v/v mixture of ethyl acetate and petroleum ether (b.p. 60-80 C.) as eluant, and the product was crystallized from a 4:1 v/v mixture of petroleum ether (b.p. 60-80 C.) and ethyl acetate. There was thus obtained 4-(4-cyano-3-trifluoromethylphenyl)-1-methylsulphonyl-2-trifluoromethylbut-3-yn-2-ol, m.p. 134-136 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Imperial Chemical Industries PLC; US4873329; (1989); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A new synthetic route of 101066-87-9

General procedure: A suspension of thiohydantoin 1 (1 mmol), aryliodide (3 mmol),copper(I) iodide (1 mmol), 1,10-phenanthroline (1 mmol), and sodiumtert-butoxide (2 mmol) in 5 ml of freshly dried dimethylformamide(DMF) was stirred for 12 h at rt with TLC checking, and then heated in the microwave oven for 30 min at 100 C. After the same work-up as above but with 100 ml of water, the product was likewise purified and recrystallized.

Reference:
Article; Aladinskiy, Vladimir A.; Averochkin, Gleb M.; Beloglazkina, Elena K.; Dlin, Egor A.; Finko, Alexander V.; Ivanenkov, Yan A.; Kalinina, Marina A.; Laikov, Dimitri N.; Majouga, Alexander G.; Mironov, Andrei V.; Skvortsov, Dmitry A.; Vorobyeva, Nataliya S.; Zyk, Nikolay V.; Bioorganic Chemistry; vol. 100; (2020);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

New downstream synthetic route of 101066-87-9

According to the analysis of related databases, 101066-87-9, the application of this compound in the production field has become more and more popular.