Category: 101-29-1

Bojarska-Dahlig, Halina published the artcileFeasibility of synthesizing 3,5-diiodo-4-pyridoxyacetic acid, the isomer of 3,5-diiodo-4-pyridone-N-acetic acid, Quality Control of 101-29-1, the publication is Acta Poloniae Pharmaceutica (1957), 457-8, database is CAplus.

The Ag salt of 3,5-diiodo-4-hydroxypyridine and ClCH₂CO₂Et in xylene or C₅H₅N give Et 3,5-diiodo-4-pyridone-N-acetate (I), m. 178-9°. The O-substituted isomer is not formed. The identity of I was established by determination of the mixed m.p. of I and of the free acid from I (m. 241-2°) with pure compounds prepared by a different method.

Acta Poloniae Pharmaceutica published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Quality Control of 101-29-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Stahl, Egon published the artcileThin layer chromatography. XII. Separation and specific detection of organic iodine compounds such as x-ray contrast materials and tyrosine derivatives, Category: iodides-buliding-blocks, the publication is Fresenius’ Zeitschrift fuer Analytische Chemie (1964), 200(5), 377-85, database is CAplus.

cf. CA 58, 12369f. Mixtures of I-containing x-ray contrast compounds are separated by thin layer chromatography on silica gel-starch using either acidic or basic eluents. The spots are detected via I release by short wavelength ultraviolet light and appearance of the blue starch-I complex. As little as 0.1 γ I can be detected.

Fresenius’ Zeitschrift fuer Analytische Chemie published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H8BNO4, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kippen, Ian published the artcileUptake of uric acid by separated renal tubules of the rabbit. II. Effects of drugs, Product Details of C7H5I2NO3, the publication is Journal of Pharmacology and Experimental Therapeutics (1977), 201(1), 226-32, database is CAplus and MEDLINE.

The effect of various drugs on the rate of uptake of uric acid [69-93-2] by separated renal tubules of the rabbit was investigated. Determinations were made of I50 values and slopes of the inhibition curves. The most potent inhibitor of uric acid uptake was sulfinpyrazone [57-96-5], with an I50 of 0.02 mM. Calcium ipodate [1151-11-7] and benzbromarone [3562-84-3] were also potent inhibitors. Uricosuric drugs, with the exception of benzobromarone, had shallow inhibition slopes. Diuretic drugs had steep inhibition slopes. More than one mechanism of action is probably involved in the inhibition of uric acid uptake in separated renal tubules by drugs.

Journal of Pharmacology and Experimental Therapeutics published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Product Details of C7H5I2NO3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hackman, R. H. published the artcileImproved methods for the preparation of the x-ray contrast media iodoxyl and diodone, HPLC of Formula: 101-29-1, the publication is Journal of the Society of Chemical Industry, London (1946), 204-5, database is CAplus.

Important modifications have been introduced in the methods of preparation of iodoxyl (di-NaN-methyl-3,5-diiodochelidamate) and diodone (3,5-diiodo-4-pyridone-1-acetic acid) by which considerably higher yields are obtainable. Improved methods of iodination and methylation are described.

Journal of the Society of Chemical Industry, London published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, HPLC of Formula: 101-29-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hammarlund, E. R. published the artcileMethods of preparing isotonic solutions by means of graphs or tables on the basis of experimentally found iso-osmotic values, Computed Properties of 101-29-1, the publication is Pharmaceutica Acta Helvetiae (1960), 593-607, database is CAplus.

Four graphical and three tabular methods for preparing isotonic aqueous solutions are described. New exptl. data is presented for 353 compounds to be used for the recommended and most practical of the methods studied for isotonicity adjustment. All the methods described may be used in practical pharmacy. The graphical methods are more accurate but consume more space than the tabular methods.

Pharmaceutica Acta Helvetiae published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Computed Properties of 101-29-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fine, Jonathan published the artcileGraph-based machine learning interprets and predicts diagnostic isomer-selective ion-molecule reactions in tandem mass spectrometry, COA of Formula: C7H5I2NO3, the publication is Chemical Science (2020), 11(43), 11849-11858, database is CAplus and MEDLINE.

Diagnostic ion-mol. reactions employed in tandem mass spectrometry experiments can frequently be used to differentiate between isomeric compounds unlike the popular collision-activated dissociation methodol. Selected neutral reagents, such as 2-methoxypropene (MOP), are introduced into an ion trap mass spectrometer where they react with protonated analytes to yield product ions that are diagnostic for the functional groups present in the analytes. However, the understanding and interpretation of the mass spectra obtained can be challenging and time-consuming. Here, we introduce the first bootstrapped decision tree model trained on 36 known ion-mol. reactions with MOP. It uses the graph-based connectivity of analytes′ functional groups as input to predict whether the protonated analyte will undergo a diagnostic reaction with MOP. A Cohen kappa statistic of 0.70 was achieved with a blind test set, suggesting substantial inter-model reliability on limited training data. Prospective diagnostic product predictions were exptl. tested for 13 previously unpublished analytes. We introduce chem. reactivity flowcharts to facilitate chem. interpretation of the decisions made by the machine learning method that will be useful to understand and interpret the mass spectra for chem. reactivity.

Chemical Science published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, COA of Formula: C7H5I2NO3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Willenbrink, J. published the artcileMechanism of excretion of urinary contrast media, Recommanded Product: 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, the publication is Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie (1959), 16-18, database is CAplus.

3,5-Di-iodo-4-pyridone-N-acetic acid (I) and 3,5-diacetamido-2,4,6-triiodobenzoic acid (II) labeled with radioiodine were injected into Hippocampus cudae, which had no glomeruli. The excretion of I was 5 times that of II. Excretion through bile and intestine was insignificant. The excretion of I in rabbits decreased with a plasma concentration up to 10 mg. % and remained constant between 20 and 1280 mg. %. Blocking the tubules with 200 mg. % p-aminohippuric acid (PAH) caused a depression of excretion to 1-10 mg. %. The rate of excretion of II remained unchanged within the range of 1 to 1280 mg. % in the plasma and was not influenced by PAH.

Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C5H12O2, Recommanded Product: 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tanner, George A. published the artcileReabsorption and secretion of p-aminohippurate and Diodrast in Necturus kidney, HPLC of Formula: 101-29-1, the publication is American Journal of Physiology (1966), 210(2), 221-31, database is CAplus and MEDLINE.

Intact animals spontaneously show net reabsorption, no net transport, or net secretion of p-aminohippurate(PAH) and Diodrast. Net reabsorption was converted to net secretion by intraarterial doses of fatty acids such as octanoate. In kidneys perfused with modified Ringer solution, strong net PAH reabsorption was observed; with 1mM octanoate, net secretion was usually produced. The action of octanoate is specific and reversible. With PAH-carboxyl-¹⁴C perfused from either the aortic or renal portal side and unlabeled PAH from the opposite side, urine PAH sp. activity differed from that of filtered PAH. Unidirectional PAH movements, calculated using a 2-compartment analysis, suggest that Diodrast inhibits reabsorptive and secretory movements, whereas octanoate inhibits primarily the reabsorptive movement. Tubular transport of PAH and Diodrast in Necturus kidney may involve active processes which move these compounds into proximal tubule cells from luminal and peritubular sides.

American Journal of Physiology published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C8H7NO4, HPLC of Formula: 101-29-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com