Category: 1000577-94-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1000577-94-5, name is 3-Bromo-4-iodobenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 1000577-94-5

General procedure: An oven-dried Schlenk tube was charged with a magneticstir bar, binucleophile 2-mercaptobenzimidazole 2 (1.0 mmol, 1.0 equiv), CuI(0.1 mmol, 10 mol %), phen (0.2 mmol, 20 mol %), and K2CO3 (2.0 mmol, 2equiv). The tube was capped and then evacuated and backfilled with nitrogen(3 times). Under a positive pressure of nitrogen, a solution of o-dihaloarene 1(1.05 mmol, 1.05 equiv) in DMF (3 mL) was added via syringe. The tube wassealed and allowed to stir at 120 C (monitored by TLC). After being cooled toroom temperature, EtOAc (40 mL) was added and the mixture was washedwith brine (20 mL 3). The organic phase was dried over Na2SO4 andconcentrated. The residue was purified by column chromatography on silicagel using petrol/EtOAc (10:1?3:1, v:v) as eluent to give product 3.

The synthetic route of 1000577-94-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gao, Jilong; Zhu, Jiaoyan; Chen, Lubin; Shao, Yingying; Zhu, Jiaqi; Huang, Yijia; Wang, Xiaoxia; Lv, Xin; Tetrahedron Letters; vol. 55; 22; (2014); p. 3367 – 3373;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 1000577-94-5, A common heterocyclic compound, 1000577-94-5, name is 3-Bromo-4-iodobenzonitrile, molecular formula is C7H3BrIN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a nitrogen stream, in a 50 mL Schlenk tube,3.52 g (11.43 mmol) of 3-bromo-4-iodobenzonitrile, 6.35 g (28.58 mmol) of 9-phenanthreneboronic acid,51 mg (0.23 mmol),218 mg (0.46 mmol) of 2-dicyclohexylphosphino-2 ‘, 4′, 6’-triisopropylbiphenyl (Xphos), 15 mL of tetrahydrofuran,And 15 mL of 2 M potassium carbonate aqueous solution were added, and the mixture was stirred at 75 C. for 15 hours. After cooling to room temperature, methanol 100 mL was added and stirred, and the precipitated solid was collected by filtration and washed with pure water and methanol.By recrystallizing (chloroform / methanol) the residue,1.62 g (3.56 mmol) of a colorless powder of 9- [4-cyano-2- (9-phenanthryl) -phenyl] – phenanthrene was isolated (yield 31%, HPLC purity 98.4%).

The synthetic route of 1000577-94-5 has been constantly updated, and we look forward to future research findings.