Some common heterocyclic compound, 88-67-5, name is 2-Iodobenzoic acid, molecular formula is C7H5IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-Iodobenzoic acid
2.48 g (10 mmol) of o-iodobenzoic acid was weighed, and 5 mL of absolute ethanol was weighed. Magnetic seeds were placed in a round bottom flask, and an appropriate amount of concentrated sulfuric acid was added thereto, and the mixture was stirred at 90 C for 12 hours, and detected by TLC, and stopped when the raw materials disappeared. reaction. The reaction solution was concentrated by a reduced pressure rotary evaporator to remove excess ethanol, and an appropriate amount of saturated NaHCO 3 was added to neutralize the remaining concentrated sulfuric acid.When no bubbles are generated, that is, when the neutralization is complete, the mixture is washed with ethyl acetate (3¡Á50 mL) and water, and the organic layer is combined, water is evaporated, and filtered, and then filtered, and then filtered, and then evaporated. The ethyl acetate was removed to give 2.50 g of ethyl iodobenzoate as a yellow oil, yield 90%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 88-67-5, its application will become more common.
Reference:
Patent; Xinxiang Medical University; Xinxiang Medical School San Quan College; Yan Fulin; Wang Yawen; Yan Jianwei; Yin Tiantian; Ma Jinshuo; (15 pag.)CN110183387; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com