Hard acid and soft nucleophile systems. 8. Reductive dehalogenation of o- and p-halophenols and their derivatives was written by Node, Manabu;Kawabata, Takeo;Ohta, Keiichiro;Fujimoto, Mayumi;Fujita, Eiichi;Fuji, Kaoru. And the article was included in Journal of Organic Chemistry in 1984.Reference of 2314-37-6 This article mentions the following:
Treatment of o– or p-halophenols and their derivatives with the AlCl3-EtSH system provides a dehalogenated product in 85-98% yield. In an example, 2-BrC6H4OMe at room temperature in CH2Cl2 containing 2.5 mol equiv AlCl3 and EtSH gave 95% PhOH in 1.5 h. Cl and F cannot be removed by this system. Electron-withdrawing groups retard the reaction rate. The method was used for dehalogenation of halonaphthols and polyhalophenols. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Reference of 2314-37-6).
3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Reference of 2314-37-6
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com