New polyhydroxylated flavon-3-ols and 3-hydroxy-2-styrylchromones: synthesis and ROS/RNS scavenging activities was written by Sousa, Joana L. C.;Proenca, Carina;Freitas, Marisa;Fernandes, Eduarda;Silva, Artur M. S.. And the article was included in European Journal of Medicinal Chemistry in 2016.COA of Formula: C8H9IO2 This article mentions the following:
New polyhydroxylated flavon-3-ols I (R = OH, OMe; R1 = OH, OMe) and 3-hydroxy-2-styrylchromones II were prepared and assessed as reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavengers. The synthetic strategy involved the preparation of 2′-hydroxychalcones (E)-XC(O)CH:CHY [X = 2-HO-3,4-(C6H5CH2O)2C6H2, 2-HO-3,4-(H3CO)2C6H2; Y = 3,4-(C6H5CH2O)2C6H3, 3,4-(H3CO)2C6H3] and 2′-hydroxycinnamylidenoacetophenones (E),(E)-XC(O)CH:CHCH:CHY from base-catalyzed aldol reaction of appropriate 2′-hydroxyacetophenones such as 3′,4′-bis(benzyloxy)-2′-hydroxyacetophenone, 2′-hydroxy-3′,4′-dimethoxyacetophenone and benzaldehydes such as 3,4-dimethoxybenzaldehyde, 3,4-bis(benzyloxy)benzaldehyde/cinnamaldehydes such as (E)-3,4-dimethoxycinnamaldehyde, (E)-3,4-bis(benzyloxy)cinnamaldehyde, followed by an Algar-Flynn-Oyamada (AFO) reaction to give the polyalkoxy(flavon-3-ols I and 3-hydroxy-2-styrylchromones II). The last step of this synthetic route consisted of the cleavage of the protecting groups affording the expected polyhydroxylated derivatives I and II. The present work consisted of the study of the in vitro scavenging activities of the synthesized compounds against the most physiol. relevant ROS [superoxide radical (O2·–), hydrogen peroxide (H2O2), hypochlorous acid (HOCl), singlet oxygen (1O2) and peroxyl radical (ROO·)] and RNS [nitric oxide (·NO) and peroxynitrite anion (ONOO–)]. Generally, all the tested new polyhydroxylated flavon-3-ols I and 3-hydroxy-2-styrylchromones II exhibited scavenging effects dependent on the concentration, and with IC50 values found within the micromolar range. This work allowed the establishment of new structure-activity relationships and brought out the knowledge about the selective choice of a structure depending on the targeted reactive species. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2COA of Formula: C8H9IO2).
4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.COA of Formula: C8H9IO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com