The Synthesis of 1H-Pyrazolo[3,4-b]quinoxaline Derivatives Oriented towards Modification of Carbocyclic Ring in the Parent Skeleton was written by Wojtasik, Katarzyna;Danel, Andrzej. And the article was included in ChemistrySelect in 2020.Safety of 4-Chloro-2-iodo-1-nitrobenzene This article mentions the following:
It was proved that the method of synthesis of 1H-pyrazolo[3,4-b]quinoxaline derivatives I [R1 = 5-Cl, 6-N(Et)2, 7-N(Et)2, etc.] (PQX), consisting of the reductive cyclization of the corresponding pyrazole derivative II [R2 = 5-Cl, 6-Cl, 7-Cl, 8-Cl] was the most universal method of PQX synthesis among the known and was regiospecific. The obtained x-chloro-1-methyl-3-phenyl-1H-pyrazolo[3,4-b]quinoxaline I [R1 = 5-Cl, 6-Cl, 7-Cl, 8-Cl, etc.] isomers were starting materials for the synthesis of N,N-diethylamine derivatives I [R1 = 5-N(Et)2, 6-N(Et)2, 7-N(Et)2, 8-N(Et)2, etc.]. The position differentiation of these substituents strongly impacted the emissive properties of the final compounds In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1Safety of 4-Chloro-2-iodo-1-nitrobenzene).
4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Safety of 4-Chloro-2-iodo-1-nitrobenzene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com