Electric Literature of 98-61-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 98-61-3, name is 4-Iodobenzenesulfonyl chloride belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
5.1.11 N-[(5-Isobutyl-1-phenyl-1H-pyrazol-3-yl)methyl]-4-iodobenzenesulfonamide (9d) Triethylamine (32.6 muL, 0.234 mmol) was added at 0 C to a solution of (5-isobutyl-3-aminomethyl-1-phenyl)pyrazole (48.7 mg, 0.212 mmol) in dichloromethane (1.0 mL). The solution was stirred for 5 min, and mixed with a solution of 4-iodobenzenesulfonyl chloride (68.2 mg, 0.223 mmol) in dichloromethane. Subsequently, the solution was warmed to room temperature, and stirred for 1 h. Then, water and a saturated sodium hydrogen carbonate solution were added to the solution before extraction with dichloromethane. The organic layer thus formed was dried over magnesium sulfate, concentrated in vacuo, and purified by column chromatography (hexane:EtOAc = 3:1 ? 2:1) to afford the title compound (86.3 mg, 82.0%). 1H NMR (400 MHz, CDCl3) delta 7.76 (d, J = 8.16 Hz, 2H), 7.53 (d, J = 8.24 Hz, 2H), 7.46-7.38 (m, 3H), 7.23 (d, J = 7.60 Hz, 2H), 5.95 (s, 1H), 5.72 (br, 1H), 4.18 (d, J = 5.80 Hz, 2H), 2.40 (d, J = 7.16 Hz, 2H), 1.75-1.68 (m, 1H), 0.81 (d, J = 6.60 Hz, 6H); 13C NMR (100 MHz, CDCl3) delta 147.6, 144.4, 139.9, 139.5, 138.1, 129.2, 128.7, 128.2, 125.7, 104.8, 99.7, 41.0, 35.0, 28.3, 22.4.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodobenzenesulfonyl chloride, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Kim, Jung Hyun; Keum, Gyochang; Chung, Hesson; Nam, Ghilsoo; European Journal of Medicinal Chemistry; vol. 123; (2016); p. 665 – 672;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com