Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro was written by Thames, Joy E.;Waters, Charles D. III;Valle, Coralie;Bassetto, Marcella;Aouadi, Wahiba;Martin, Baptiste;Selisko, Barbara;Falat, Arissa;Coutard, Bruno;Brancale, Andrea;Canard, Bruno;Decroly, Etienne;Seley-Radtke, Katherine L.. And the article was included in Bioorganic & Medicinal Chemistry in 2020.Safety of 4,5-Diiodo-1H-imidazole This article mentions the following:
Flaviviruses, such as Dengue (DENV) and Zika (ZIKV) viruses, represent a severe health burden. There are currently no FDA-approved treatments, and vaccines against most flaviviruses are still lacking. We have developed several flexible analogs (“fleximers”) of the FDA-approved nucleoside Acyclovir that exhibit activity against various RNA viruses, demonstrating their broad-spectrum potential. The current study reports activity against DENV and Yellow Fever Virus (YFV), particularly for compound 1. Studies to elucidate the mechanism of action suggest the flex-analog triphosphates, especially 1-TP, inhibit DENV and ZIKV methyltransferases, and a secondary, albeit weak, effect on the DENV RNA-dependent RNA polymerase was observed at high concentrations The results of these studies are reported herein. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Safety of 4,5-Diiodo-1H-imidazole).
4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Safety of 4,5-Diiodo-1H-imidazole
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com