Related Products of 4387-36-4,Some common heterocyclic compound, 4387-36-4, name is 2-Iodobenzonitrile, molecular formula is C7H4IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Weigh 2.28 g of o-iodobenzonitrile and 1.13 g of phenylacetylene. Bis-triphenylphosphine palladium dichloride 140mg, 19 mg of cuprous iodide is dissolved in 250 mL of triethylamine. The reaction was carried out under nitrogen at 60 C for 12 h. Thin chromatography was used to detect the reaction process. After the reaction is completed, it is filtered with diatomaceous earth. Rotating off the solvent triethylamine, dry loading by column chromatography to obtain a pale yellow solid 1.86 g (yield 91%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodobenzonitrile, its application will become more common.
Reference:
Patent; Zhengzhou University; Chen Xiaolan; Sun Kai; Yu Bing; Qu Lingbo; Sun Yuanqiang; (8 pag.)CN108689892; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com