Metal-Free Catalytic Asymmetric Fluorination of Keto Esters Using a Combination of Hydrogen Fluoride (HF) and Oxidant: Experiment and Computation was written by Pluta, Roman;Krach, Patricia E.;Cavallo, Luigi;Falivene, Laura;Rueping, Magnus. And the article was included in ACS Catalysis in 2018.Synthetic Route of C8H7IO4 This article mentions the following:
In the presence of nonracemic iodoarenes I [R = H, 3,5-(F3C)2C6H3], fused β-keto esters such as Et 1-oxo-2-indanecarboxylate underwent enantioselective fluorination with Et3N·5 HF mediated by mCPBA in CHCl3 to yield α-fluoro-β-keto esters such as II in 18-71% yields and in 83:17-96:4 er; thus, nucleophilic fluoride sources could be used as fluorinating reagents. The mechanism of the fluorination was studied using DFT calculations of transition states and intermediates and their free energies; attempted fluorination using a nonracemic aryliodine difluoride did not give fluorination product, indicating the importance of HF in the fluorination. In the experiment, the researchers used many compounds, for example, Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7Synthetic Route of C8H7IO4).
Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Synthetic Route of C8H7IO4
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com