Spiroannulation by alkylation and reductive cyclization of nitriles was written by Rychnovsky, Scott D.;Takaoka, Leo R.. And the article was included in Angewandte Chemie, International Edition in 2003.Recommanded Product: 10297-05-9 This article mentions the following:
Spirocyclic rings were prepared from 2-cyanotetrahydropyrans. E.g., lithiation of 2-cyano-2-alkenyltetrahydropyran I (R = n-C5H11), prepared from 2-cyano-6-pentyltetrahydropyran, by lithium di-tert-butylbiphenylide led to the spirocyclic compound II. This two step sequence, alkylation and reductive cyclization, is used to generate five- and six-membered rings, and is highly stereoselective. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Recommanded Product: 10297-05-9).
1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 10297-05-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com