TMSCF3 as a Convenient Source of CF2=CF2 for Pentafluoroethylation, (Aryloxy)tetrafluoroethylation, and Tetrafluoroethylation was written by Li, Lingchun;Ni, Chuanfa;Xie, Qiqiang;Hu, Mingyou;Wang, Fei;Hu, Jinbo. And the article was included in Angewandte Chemie, International Edition in 2017.Application In Synthesis of 4-Iodo-1,2-dimethoxybenzene This article mentions the following:
A new method for the on-site preparation of tetrafluoroethylene (TFE) and a procedure for its efficient use in fluoroethylation reactions were developed using a simple two-chamber system. The on-site preparation of TFE was accomplished by dimerization of difluorocarbene derived from (trifluoromethyl)trimethylsilane (TMSCF3) under mild conditions. TFE was further used for pentafluoroethylation of various aryl iodides alkylation reactions, such as (aryloxy)tetrafluoroethylation of aryl and heteroaryl iodides and tetrafluoroethylation of heteroatom nucleophiles, such as phenols, alcs., thiols and amines. This work not only demonstrates a convenient and safe approach for the generation and use of TFE in academic laboratories, but also provides a new strategy for pentafluoroethylation. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Application In Synthesis of 4-Iodo-1,2-dimethoxybenzene).
4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application In Synthesis of 4-Iodo-1,2-dimethoxybenzene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com