Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections was written by Brown, Matthew F.;Reilly, Usa;Abramite, Joseph A.;Arcari, Joel T.;Oliver, Robert;Barham, Rose A.;Che, Ye;Chen, Jinshan Michael;Collantes, Elizabeth M.;Chung, Seung Won;Desbonnet, Charlene;Doty, Jonathan;Doroski, Matthew;Engtrakul, Juntyma J.;Harris, Thomas M.;Huband, Michael;Knafels, John D.;Leach, Karen L.;Liu, Shenping;Marfat, Anthony;Marra, Andrea;McElroy, Eric;Melnick, Michael;Menard, Carol A.;Montgomery, Justin I.;Mullins, Lisa;Noe, Mark. C.;O’Donnell, John;Penzien, Joseph;Plummer, Mark S.;Price, Loren M.;Shanmugasundaram, Veerabahu;Thoma, Christy;Uccello, Daniel P.;Warmus, Joseph S.;Wishka, Donn G.. And the article was included in Journal of Medicinal Chemistry in 2012.Reference of 85356-68-9 This article mentions the following:
In this paper, the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogs of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid I, is presented. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9Reference of 85356-68-9).
1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Reference of 85356-68-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com