Synthesis and biological evaluation of a novel anti-malarial lead was written by Hammond, Nicholas L.;Choi, Seoung-ryoung;Carvalho, Paulo;Liu, Hua;Khan, Shabana;Avery, Mitchell A.. And the article was included in Medicinal Chemistry Research in 2011.Reference of 15813-09-9 This article mentions the following:
Malaria is re-emerging in many tropical areas of the world and is often fatal due to drug resistance, leading to about a million deaths each year. Multiple drug resistance has required new efforts in drug discovery and development. Thus, the search for new drugs operating by novel mechanisms of action is receiving increased attention. Herein the synthesis and biol. evaluation of a novel anti-malarial with micromolar activity against resistant strains of the parasite is reported. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Reference of 15813-09-9).
4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Reference of 15813-09-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com