Silicon-Directed Oxa-Pictet-Spengler Cyclization and an Unusual Dimerization of 2-Trimethylsilanyl Tryptophols was written by Zhang, Xuqing;Li, Xiaojie;Lanter, James C.;Sui, Zhihua. And the article was included in Organic Letters in 2005.SDS of cas: 220185-63-7 This article mentions the following:
The tetrahydropyrano[3,4-b]indoles I (n = 1, 2; R1 = H, CN, Cl, NO2, F, CF3, CO2Me; R2 = H, CF3, Cl; R3 = Me; R4 = Me, MeS, EtS, BnS) were synthesized from 2-(2-trimethylsilanyl-1H-indol-3-yl)alkanols II and various ketones or aldehydes through silicon-directed oxa-Pictet-Spengler cyclizations. An unusual reaction led to the dimeric products III when some of II was treated with acetone using BF3 as the catalyst. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7SDS of cas: 220185-63-7).
4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.SDS of cas: 220185-63-7
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com