6828-35-9, name is 5-Chloro-2-iodoaniline, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 6828-35-9
General procedure: A mixture of 2-iodo aniline/2-iodo phenol (0.25 mmol), Pd-NHC (5 mg, 2 mol%), Mo(CO)6 (0.50 mmol, 132 mg) was taken in round bottomed flask and backfilled with nitrogen three times. Alkyne (0.50 mmol), DMF (2 ml) and Me2NH (4 equiv) were added to the reaction mixture via syringe. The reaction mixture was heated at 95 C until the completion of the reaction. Afterwards, the reaction mixture was poured into the water and extracted with ethyl acetate (3¡Á10 ml). The organic phase was dried over Na2SO4 and concentrated under reduced pressure. The residue was purified through column chromatography using ethyl acetate and petroleum ether as eluents.
The synthetic route of 6828-35-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ghosh, Prasanjit; Nandi, Aritra Kumar; Das, Sajal; Tetrahedron Letters; vol. 59; 21; (2018); p. 2025 – 2029;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com