Study on mercaptopyridinecarboxylic acids. Part III. Preparation of esters, ethers and ether-esters of mercaptopyridinecarboxylic acids was written by Lejeune, R.;Thunus, L.. And the article was included in Journal de Pharmacie de Belgique in 1980.Formula: C6H4INO2 This article mentions the following:
Pyridinecarboxylic acids I (R = halo) were treated with thiourea, KSH, and Na2S-S and the products were converted to the resp. mercapto acids II. Thus, 2-chloro-3-pyridinecarboxylic acid was heated with thiourea, and the product was treated with N2H4 to yield the resp. II. II were etherified by MeI and esterified by MeOH and CH2N2. In the experiment, the researchers used many compounds, for example, 3-Iodopicolinic acid (cas: 73841-32-4Formula: C6H4INO2).
3-Iodopicolinic acid (cas: 73841-32-4) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Formula: C6H4INO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com