Iodothiophenes and Related Compounds as Coupling Partners in Copper-Mediated N-Arylation of Anilines was written by Bouarfa, Salima;Bentabed-Ababsa, Ghenia;Erb, William;Picot, Laurent;Thiery, Valerie;Roisnel, Thierry;Dorcet, Vincent;Mongin, Florence. And the article was included in Synthesis in 2021.Synthetic Route of C8H5IS This article mentions the following:
N-Arylation of various 2-acylated anilines 2-NH2-5-R-C6H3C(O)R1 (R = H, Cl; R1 = H, Me, Ph) with different electron-rich heteroaryl iodides R2I (R2 = thiophen-2-yl, 1-benzothiophen-3-yl, furan-2-yl, etc.) was achieved by using activated copper and potassium carbonate in di-Bu ether at reflux. The reactivity of the different heteroaryl iodides and anilines employed was discussed and rationalized on the basis of their electronic features. Subsequent cyclization by aromatic electrophilic substitution easily took place in the case of C2-free (benzo)thienyl I (X = O, S) or C3-free (benzo)furyl derivatives, II affording original tri- and tetracycles. The antiproliferative activity of most of them was evaluated in A2058 melanoma cells and revealed four chlorinated tetracycles as effective growth inhibitors. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Synthetic Route of C8H5IS).
3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Synthetic Route of C8H5IS
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com