Palladium-Catalyzed, Norbornene-Mediated, ortho-Amination ipso-Amidation: Sequential C-N Bond Formation was written by Whyte, Andrew;Olson, Maxwell E.;Lautens, Mark. And the article was included in Organic Letters in 2018.COA of Formula: C7H4ClIO2 This article mentions the following:
A palladium-catalyzed, norbornene-mediated ortho- and ipso-C-N bond-forming Catellani reaction is reported. This reaction proceeds through a sequential intermol. amination followed by intramol. cyclization of a tethered amide. The products, ortho-aminated dihydroquinolinones, e.g. I, were generated in moderate to good yields and are present in bioactive mols. This work highlights the challenge of competing intra- vs intermol. palladium-catalyzed processes. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-iodobenzoic acid (cas: 13420-63-8COA of Formula: C7H4ClIO2).
2-Chloro-6-iodobenzoic acid (cas: 13420-63-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.COA of Formula: C7H4ClIO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com