Diasteroselective Synthesis of New Spiropiperidine Scaffolds from the CN(R,S) Building Block was written by Roulland, Emmanuel;Cecchin, Fabrice;Husson, Henri-Philippe. And the article was included in Journal of Organic Chemistry in 2005.Recommanded Product: 10297-05-9 This article mentions the following:
A methodol. allowing the construction of spiropiperidine scaffolds, e.g. I or II, similar to those found in naturally occurring alkaloids was been developed. This approach begins with the well-established CN(R,S) strategy in which the spiro-center was built via intramol. attack of a nitrile function in oxazolopyridinecarbonitriles, e.g. III (n = 1, 2), by an organolithium species obtained by halogen/Li exchange reaction mediated by either t-BuLi or Li naphthalenide. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Recommanded Product: 10297-05-9).
1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 10297-05-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com