Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. III. Synthesis and antitumor activity of 3-phenylpiperazinyl-1-trans-propenes was written by Naito, Hiroyuki;Ohsuki, Satoru;Atsumi, Ryo;Minami, Megumi;Mochizuki, Mineko;Hirotani, Kenji;Kumazawa, Eiji;Ejima, Akio. And the article was included in Chemical & Pharmaceutical Bulletin in 2005.Formula: C6H5FIN This article mentions the following:
A series of 3-[4-phenyl-1-piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-propenes, e.g., I, and related compounds were synthesized and evaluated by their cytotoxic activity against several tumor cell lines in vitro and in vivo antitumor activity against some tumor models when administered both i.p. and orally. Compounds with the 3-chloropyridin-2-yl group and the 3-fluoro-5-substituted phenylpiperazinyl group showed significantly potent cytotoxicity by in vitro testing. Among them, the 3-cyano-5-fluorophenyl derivative I exhibited potent antitumor activity against several tumor cells including human carcinoma without causing undesirable effects in mice. In the experiment, the researchers used many compounds, for example, 3-Fluoro-5-iodoaniline (cas: 660-49-1Formula: C6H5FIN).
3-Fluoro-5-iodoaniline (cas: 660-49-1) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Formula: C6H5FIN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com