In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Methyl 5-bromo-2-iodobenzoate
To a stirred mixture of NaBH4 (11.18 g, 0.296 mol) in EtOH (200 ML) at 5 C. was added the product from Example 62A (50.4 g, 0.148 mol) in THF (100 ML).The mixture was alowed to warm to room temperature and stirred for 18 hours.The mixture was treated with additional NaBH4 (8.4 g, 0.222 mol) and was stirred for 22 hours.The mixture was cooled to 0 C., treated with 100 ML of 15% aqueous citric acid slowly, and extracted with 600 ML of CH2Cl2.The organic phase was washed with 200 ML of 15% NaCl and concentrated to provide the title compound. 1H NMR (CDCl3, 400 MHz) delta 7.64 (d, J=8 Hz, 1H), 7.61 (d, J=4 Hz, 1H), 7.12 (dd, J=4, 8 Hz, 1H), 4.63 (d, J=8 Hz, 2H), 1.98 (t, J=8 Hz, 1H). MS (DCl/NH3) [M+NH4]+ at 330, [M+NH4-H2O]+ at 312.
The synthetic route of 181765-86-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Sharma, Padam N.; Bennani, Youssef L.; US2004/92521; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com