Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer′s Disease was written by Ratni, Hasane;Alker, Andre;Bartels, Bjoern;Bissantz, Caterina;Chen, Weichun;Gerlach, Irene;Limberg, Anja;Lu, Mingqiu;Neidhart, Werner;Pichereau, Solen;Reutlinger, Michael;Rodriguez-Sarmiento, Rosa-Maria;Jakob-Roetne, Roland;Schmitt, Georg;Zhang, Eric;Baumann, Karlheinz. And the article was included in ACS Medicinal Chemistry Letters in 2020.Safety of 1-Chloro-4-iodobutane This article mentions the following:
γ-Secretase (GS) is a key target for the potential treatment of Alzheimer′s disease. While inhibiting GS led to serious side effects, its modulation holds a lot of potential to deliver a safe treatment. Herein, we report the discovery of a potent and selective gamma secretase modulator (GSM) (S)-3 (RO7185876), belonging to a novel chem. class, the triazolo-azepines. This compound demonstrates an excellent in vitro and in vivo DMPK profile. Furthermore, based on its in vivo efficacy in a pharmacodynamic mouse model and the outcome of the dose range finding (DRF) toxicol. studies in two species, this compound was selected to undergo entry in human enabling studies (e.g., GLP toxicol. and scale up activities). In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Safety of 1-Chloro-4-iodobutane).
1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Safety of 1-Chloro-4-iodobutane
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com