Rosuvastatin based novel 3-substituted isocoumarins / 3-alkylidenephthalides: Ultrasound assisted synthesis and identification of new anticancer agents was written by Kumar, Jetta Sandeep;Thirupataiah, B.;Medishetti, Raghavender;Ray, Aramita;Bele, Shilpak Dilip;Hossain, Kazi Amirul;Reddy, Gangireddy Sujeevan;Edwin, Rebecca Kristina;Joseph, Alex;Kumar, Nitesh;Shenoy, Gautham G.;Rao, C. Mallikarjuna;Pal, Manojit. And the article was included in European Journal of Medicinal Chemistry in 2020.Related Products of 123278-03-5 This article mentions the following:
A new class of 3-substituted isocoumarin/3-alkylidenephthalide based novel small mols. derived from rosuvastatin were designed and synthesized via the ultrasound assisted Cu-mediated coupling-cyclization in a single pot with remarkable regioselectivity. The phthalides were generally obtained at lower temperature whereas the use of elevated temperature afforded isocoumarins. Two compounds e.g. I and II showed promising cytotoxic effects when tested against HCT 116, HepG2 and PA-1 cell lines at 10μM. Indeed, II was found to be a potent cytotoxic agent (IC50 ∼ 0.76-4.51μM). Both I and II were tested for their effects on PANC-1 cells. Considerable decrease in p-Akt substrates shown by II and I at 50μM (western blot anal.) indicated their ability to inhibit p-Akt signal transduction pathway and arresting growth of PANC-1 cells in vitro. This was further supported by the cytotoxic effect of II on PANC-1 cells (MTT assay) that was better than rosuvastatin. While none of I and II showed any significant effect on non-cancerous HEK cell line (indicating their potential selectivity towards cancer cells) these compounds were further evaluated for their toxicities in Zebrafish embryo. The NOAEL (No Observed Adverse Effect Level) for teratogenicity, hepatotoxicity and cardiotoxicity was found to be 100μM for both compound Thus, II as a novel and potent but safer cytotoxic agent with potential to treat colorectal/ovarian and pancreatic cancer is of further medicinal interest. In the experiment, the researchers used many compounds, for example, 3-Chloro-2-iodobenzoic acid (cas: 123278-03-5Related Products of 123278-03-5).
3-Chloro-2-iodobenzoic acid (cas: 123278-03-5) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Related Products of 123278-03-5
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com