Construction of peptide macrocycles via palladium-catalyzed multiple S-arylation: An effective strategy to expand the structural diversity of cross-linkers was written by Chu, Xin;Shen, Linhua;Li, Bo;Yang, Peng;Du, Chengzhuo;Wang, Xiaoye;He, Gang;Messaoudi, Samir;Chen, Gong. And the article was included in Organic Letters in 2021.Quality Control of Bis(2-iodothiophen-3-yl)methanone This article mentions the following:
A simple and versatile method for macrocyclizing unprotected native peptides with a wide range of easily accessible diiodo and triiodoarene reagents via the palladium-catalyzed multiple S-arylation of cysteine residues is developed. Iodoarenes with different arene and heteroarene cores can be incorporated into peptide macrocycles of varied ring sizes and amino acid compositions with high efficiency and selectivity under mild conditions. In the experiment, the researchers used many compounds, for example, Bis(2-iodothiophen-3-yl)methanone (cas: 474416-61-0Quality Control of Bis(2-iodothiophen-3-yl)methanone).
Bis(2-iodothiophen-3-yl)methanone (cas: 474416-61-0) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Quality Control of Bis(2-iodothiophen-3-yl)methanone
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com