Adding a certain compound to certain chemical reactions, such as: 19094-56-5, name is 2-Chloro-5-iodobenzoic acid, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19094-56-5, Quality Control of 2-Chloro-5-iodobenzoic acid
STEP A:A 5.0 L four-necked round bottom flask was charged with 2-chloro-5- iodobenzoic acid (470.8 g, 1.66 mol), CH2CI2 (1.6 L) and DMF (5.0 ml_, 0.03 mol) at ambient temperature (2O0C). Oxalyl chloride (170 ml_, 1.94 mol) was added such that the internal temperature was maintained below 250C. The addition was slightly exothermic; vigorous gas evolution occurred. The resulting mixture was stirred overnight at ambient temperature, under argon, then the volatiles were removed under reduced pressure. The resulting residue (an acid chloride compound) was diluted with dichloromethane (500 ml_) and set aside under a nitrogen atmosphere.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-5-iodobenzoic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; MITSUBISHI TANABE PHARMA CORPORATION; WO2009/35969; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com