Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD) was written by Lagu, Bharat;Kluge, Arthur F.;Tozzo, Effie;Fredenburg, Ross;Bell, Eric L.;Goddeeris, Matthew M.;Dwyer, Peter;Basinski, Andrew;Senaiar, Ramesh S.;Jaleel, Mahaboobi;Tiwari, Nirbhay Kumar;Panigrahi, Sunil K.;Krishnamurthy, Narasimha Rao;Takahashi, Taisuke;Patane, Michael A.. And the article was included in ACS Medicinal Chemistry Letters in 2018.Recommanded Product: 15813-09-9 This article mentions the following:
Arylheterocyclylmethylphenoxyalkanoic and -alkenoic acids such as I were prepared as selective activators of PPARδ for potential use in improving mitochondrial function and for treatment of Duchenne muscular dystrophy (DMD); the heterocyclyl moiety was designed to mimic the cis-amide conformation found in the crystal structure of a previously prepared PPARδ activator to the ligand binding domain of PPARδ. The activation of PPARδ, selectivities for PPARδ over PPARα and PPARγ, and pharmacokinetics (half-lives, clearance, and AUC) in mice were determined for the compounds I (MA-0204) was a potent, selective PPARδ modulator with good pharmacokinetic properties. I was tested in vivo in mice and in myoblasts isolated from a DMD patient; I altered the expression of PPARδ target genes and improved fatty acid oxidation, indicating that I may be useful for treating DMD. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Recommanded Product: 15813-09-9).
4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Recommanded Product: 15813-09-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com