Design, synthesis, antileishmanial, and antifungal biological evaluation of novel 3,5-disubstituted isoxazole compounds based on 5-nitrofuran scaffolds was written by Trefzger, Ozildeia S.;Barbosa, Natalia V.;Scapolatempo, Renata L.;das Neves, Amarith R.;Ortale, Maria L. F. S.;Carvalho, Diego B.;Honorato, Antonio M.;Fragoso, Mariana R.;Shuiguemoto, Cristiane Y. K.;Perdomo, Renata T.;Matos, Maria F. C.;Chang, Marilene R.;Arruda, Carla C. P.;Baroni, Adriano C. M.. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2020.Application In Synthesis of 4-Iodo-1,2-dimethoxybenzene This article mentions the following:
Nitrofurylisoxazoles such as I were prepared from 1,3-dipolar cycloadditions of a nitrile oxide generated in situ from a nitrofurylhydroximoyl chloride with alkynes and tested for their antileishmanial and antifungal activities and toxicities. The antileishmanial activity of nitrofurylisoxazoles was assayed against the promastigote and amastigote forms of Leishmania (Leishmania) amazonensis, while the compounds were also tested against five Candida species for their antifungal activity; I inhibited both amastigotes and promastigotes, while inhibiting the growth of the five Candida species tested. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Application In Synthesis of 4-Iodo-1,2-dimethoxybenzene).
4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Application In Synthesis of 4-Iodo-1,2-dimethoxybenzene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com