Synthesis of functionalized 3-isochromanones via metal-free intramolecular alkoxylation-initiated cascade cyclization was written by Zhang, Ying-Qi;Zhu, Xin-Qi;Xu, Yin;Bu, Hao-Zhen;Wang, Jia-Le;Zhai, Tong-Yi;Zhou, Jin-Mei;Ye, Long-Wu. And the article was included in Green Chemistry in 2019.Product Details of 877264-43-2 This article mentions the following:
A metal-free intramol. alkoxylation-initiated cascade cyclization of allyl ether-tethered ynamides was developed. Various highly functionalized 3-isochromanones were obtained in generally good to excellent yields under mild reaction conditions. Moreover, this asym. cyclization was also realized via a stereocontrolled [3,3] rearrangement by employing a traceless chiral directing group. In addition, an unexpected [1,3] O-to-C rearrangement was observed in the case of the ynamide substrate bearing a phenyl-substituted alkene, which was distinctively different from the related gold catalysis. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Product Details of 877264-43-2).
(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Product Details of 877264-43-2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com