Related Products of 103962-05-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 103962-05-6, name is 1-Iodo-4-(trifluoromethoxy)benzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
At room temperature, 2-nitro-4-methoxybenzoic acid (0.4 mmol, 1 equiv), elemental selenium (1.2mmol, 3equiv), 4- trifluoromethoxy-iodobenzene (1.2mmol, 3equiv), Cu (OAc) 2 (0.04mmol), 1,10- phenanthroline (0.04 mmol), potassium carbonate (1.2mmol, 3equiv) and 2mL of toluene was added to the reaction tube, then filled with oxygen, and substituted three times, the oxygen the reaction environment, the reaction was stirred at a temperature of 100 deg.] C 24h. By the end of the reaction was monitored by thin layer chromatography, the reaction mixture was cooled, filtered and then ethyl acetate was added, and then spin off the solvent, the product obtained was isolated by column chromatography (eluent: petroleum ether: diethyl ether = 98), the product is yellow liquid, yield 91percent, by weight of the product is 143mg.
The synthetic route of 1-Iodo-4-(trifluoromethoxy)benzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wenzhou Medical University; Wu Ge; (20 pag.)CN107188841; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com