Benoit, Adam R. published the artcileSynthesis and evaluation of N-alkyl-9-aminoacridines with antibacterial activity, SDS of cas: 165534-79-2, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(14), 3014-3017, database is CAplus and MEDLINE.
A series of 9-(alkylamino)acridine derivatives was prepared and evaluated for activity against two strains of methicillin-resistant and one strain of methicillin-sensitive Staphylococcus aureus. Results are presented that show a clear structure activity relationship between the N-alkyl chain length and antibacterial activity with peak MIC99 values of 2-3 μM for alkyl chains ranging from 10 to 14 carbons in length. Although prior work has linked the function of acridine-based compounds to intercalation and topoisomerase inhibition, the present results show that 9-(alkylamino)acridine derivatives likely function as amphiphilic membrane-active disruptors potentially in a similar manner as quaternary ammonium antimicrobial agents. The synthesis of the target compounds was achieved by a reaction (substitution) of 9-(phenoxy)acridine or (4-methyl-1-piperazinyl)(9-phenoxy-3-acridinyl)methanone or 9,10-dihydro-9-oxo-3-acridinecarboxylic acid (amidation) with 1-alkanamine derivatives The title compounds thus formed included N-(alkyl)-9-acridinamine derivatives and (4-methyl-1-piperazinyl)[9-[(alkyl)amino]-3-acridinyl)methanone derivatives and 9,10-dihydro-9-oxo-N-alkyl-3-acridinecarboxamide derivatives
Bioorganic & Medicinal Chemistry Letters published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, SDS of cas: 165534-79-2.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com