Clausen, Rasmus P. published the artcileThe Glutamate Receptor GluR5 Agonist (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic Acid and the 8-Methyl Analogue: Synthesis, Molecular Pharmacology, and Biostructural Characterization, HPLC of Formula: 161370-66-7, the publication is Journal of Medicinal Chemistry (2009), 52(15), 4911-4922, database is CAplus and MEDLINE.
The design, synthesis, and pharmacol. characterization of a highly potent and selective glutamate GluR5 agonist is reported. (S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid (I) is the 8-Me analog of (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid (II). I displays an improved selectivity profile compared to II. A versatile stereoselective synthetic route for this class of compounds is presented along with the characterization of the binding affinity of I to ionotropic glutamate receptors (iGluRs). Functional characterization of I at cloned iGluRs using a calcium imaging assay and voltage-clamp recordings show a different activation of GluR5 compared to (S)-glutamic acid, kainic acid, and (S)-2-amino-3-(3-hydroxy-5-tert-butyl-4-isoxazolyl)propionic acid as previously demonstrated for II. An X-ray crystallog. anal. of II and computational analyses of II and I bound to the GluR5 agonist binding domain (ABD) are presented, including a watermap anal., which suggests that water mols. in the agonist binding site are important selectivity determinants.
Journal of Medicinal Chemistry published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, HPLC of Formula: 161370-66-7.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com