Baciocchi, Enrico published the artcileHomolytic substitution reactions of electron-rich pentatomic heteroaromatics by electrophilic carbon-centered radicals. Synthesis of α-heteroarylacetic acids, Application of Ethyl 2-Iodopropionate, the publication is Journal of Organic Chemistry (1992), 57(25), 6817-20, database is CAplus.
Efficient and selective homolytic substitutions (55-90% yields) of pyrrole, indole, and some pyrrole derivatives have been carried out using ambiphilic and electrophilic carbon centered radicals, generated in DMSO by Fe2+/H2O2 and α-cyano-, α-carbonyl-, and α,α’-dicarbonylalkyl iodides. The reaction is highly successful with pyrroles substituted by electron-withdrawing groups, which allowed an efficient synthesis of Tolmetin. A few extensions of this reaction to furan and thiophene are described. Thus, homolytic substitution of pyrrole with ICHRR1 (R = H, R1 = CO2Me, cyano; R = R1 = CO2Me) gave 2-substituted pyrroles I.
Journal of Organic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application of Ethyl 2-Iodopropionate.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com