Upadhyay, Prabhat K. published the artcileSynthesis and antimicrobial screening of some 1,3,4-oxadiazoles and their molecular properties prediction through ‘rule of five’, SDS of cas: 39115-95-2, the publication is Pakistan Journal of Pharmaceutical Sciences (2019), 32(3), 1025-1032, database is CAplus and MEDLINE.
In the current study, a series of 5-(4-substituted phenyl)-1,3,4-oxadiazole-2-thiols I (R = F, Cl, Br, I, Me, OMe, OH, OEt) were prepared from 4-substituted benzoic acid hydrazides 4-RC6H4C(O)NHNH2. All these synthesized compounds I were investigated for their antibacterial activities against bacterial strains i.e. Staphylococcus aureus, Bacillus substilis, Escherichia coli and Pseudomonas aeruginosa. The strains, Aspergillus niger and Candida albicans were also examined for antifungal screening. The zone of inhibition was measured and percentage inhibition was calculated by comparing with standard drug. The min. inhibitory concentrations (MICs) of potent synthesized compounds I were determined Then, all the synthesized compounds I were computed to assess the drug-like properties through Lipinski’s rule of five. The results of in-vitro assay showed that the compounds I (R = F, Cl, I) possess significant antibacterial activity, whereas compounds I (R = F, OMe, OEt) possess significant antifungal activity. The predicted drug likeness score of all these compounds I were also meritorious among 1,3,4-oxadiazoles. The results recommended that these compounds I might be used in future to generate derivatives for emergent antimicrobial agents with improved pharmacokinetic profile.
Pakistan Journal of Pharmaceutical Sciences published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C18H28B2O4, SDS of cas: 39115-95-2.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com