Kratky, Martin published the artcileIodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents, Category: iodides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2021), 116209, database is CAplus and MEDLINE.
Here in, authors synthesized and screened twenty-two iodinated hydrazide-hydrazones I (R1 = H, Me, t-Bu, etc.; R2 = 2-OH, 4-OH), ten 1,2-diacylhydrazines II (R = H, t-Bu, CF3, etc.)and their three reduced analogs for their antibacterial, antifungal, and cytotoxic properties. Hydrazide-hydrazones were prepared by condensation of 4-substituted benzohydrazides with 2-/4-hydroxy-3,5-diiodobenzaldehydes, diacylhydrazines from identical benzohydrazides and 3,5-diiodosalicylic acid via its chloride. These compounds were investigated in vitro against eight bacterial and eight fungal strains. The derivatives were found potent antibacterial agents against Gram-pos. cocci including methicillin-resistant Staphylococcus aureus with the lowest values of min. inhibitory concentrations (MIC) of 7.81μM. Four compounds inhibited also human pathogenic fungi (MIC of ≥ 1.95μM). The derivatives had different degrees of cytotoxicity for HepG2 and HK-2 cell lines (IC50 values from 11.72 and 26.80μM, resp.) and normal human cells exhibited lower sensitivity. The apoptotic effect was also investigated. In general, the presence of 3,5-diiodosalicylidene scaffold in compd I (R2 = 2-OH) is translated into enhanced both antimicrobial and cytotoxic properties whereas its 4-hydroxy isomers I (R2 = 4-OH) share a low biol. activity. Compounds II have a non-homogeneous activity profile. Focusing on 4-substituted benzohydrazide part, the presence of an electron-withdrawing group (F, Cl, CF3, NO2) was found to be beneficial.
Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com