A novel synthetic approach towards chiral QUINAP via diastereomeric sulfoxide intermediates was written by Thaler, Tobias;Geittner, Florian;Knochel, Paul. And the article was included in Synlett in 2007.Application In Synthesis of 2-Bromo-1-iodonaphthalene The following contents are mentioned in the article:
A novel enantioselective synthesis of chiral QUINAP is described. Hereby, the separation of the diastereomers was achieved by the preparation and simple chromatog. separation of chiral sulfoxide intermediates. Subsequent sulfoxide-lithium exchange, quenching with Ph2PCl and sulfur, and then desulfurization with Raney-Ni provided (R)- and (S)-QUINAP in 54-56% overall yield. This study involved multiple reactions and reactants, such as 2-Bromo-1-iodonaphthalene (cas: 676267-05-3Application In Synthesis of 2-Bromo-1-iodonaphthalene).
2-Bromo-1-iodonaphthalene (cas: 676267-05-3) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Application In Synthesis of 2-Bromo-1-iodonaphthalene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com