Access to 2-substituted-2H-indazoles via a copper-catalyzed regioselective cross-coupling reaction was written by Zhang, Rong;Liu, Zheng;Peng, Qiujun;Zhou, Yijun;Xu, Lanting;Pan, Xianhua. And the article was included in Organic & Biomolecular Chemistry in 2018.Application In Synthesis of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate The following contents are mentioned in the article:
A CuCl catalyzed C-N cross-coupling reaction using com. available 1H-indazoles with aryliodonium salts was described. The methodol. featured ample structural versatility, affording 2-substituted-2H-indazoles in good yields and complete N(2)-regiocontrol. Furthermore, the utility of the reaction was demonstrated in the synthesis of a known estrogen receptor β agonist. Mechanistic studies using d. functional theory calculations suggested that the complete regioselectivity was attributed to the only weak base TfO– in this system which could not deprotonate indazoles and the catalyst oxidation process was the rate-determining step. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Application In Synthesis of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate).
Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application In Synthesis of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com