Transition metal-free N-arylation of secondary amides through iodonium salts as aryne precursors was written by Wang, Ming;Huang, Zhijian. And the article was included in Organic & Biomolecular Chemistry in 2016.Computed Properties of C17H18F3IO3S The following contents are mentioned in the article:
Transition metal-free approach was developed for N-arylation of secondary amides by using a diaryliodonium salt as a benzyne precursor to afford corresponding tertiary amides RR1NC(O)R2 [R = n-Bu, Ph; R1 = Et, Ph, Bn, etc.; R2 = Me, Ph] with high regio- and chemoselectivity. This novel benzyne precursor, which could be prepared easily by a one step process from an aryl iodide, showed different reactivities with previous benzyne precursors in the N-arylation reaction. Mechanistic studies confirmed the involvement of benzyne species (generated in situ from the diaryliodonium salts) as key intermediates. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Computed Properties of C17H18F3IO3S).
Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Computed Properties of C17H18F3IO3S
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com