A Modular Flow Design for the meta-Selective C-H Arylation of Anilines was written by Gemoets, Hannes P. L.;Laudadio, Gabriele;Verstraete, Kirsten;Hessel, Volker;Noel, Timothy. And the article was included in Angewandte Chemie, International Edition in 2017.Category: iodides-buliding-blocks The following contents are mentioned in the article:
Described herein is an effective and practical modular flow design for the meta-selective C-H arylation of anilines. The design consists of four continuous-flow modules (i.e., diaryliodonium salt synthesis, meta-selective C-H arylation, inline copper extraction, and aniline deprotection) which can be operated either individually or consecutively to provide direct access to meta-arylated anilines. With a total residence time of 1 h, the desired product could be obtained in high yield and excellent purity without the need for column chromatog., and the residual copper content meets the standards for parenterally administered pharmaceutical substances. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Category: iodides-buliding-blocks).
Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Category: iodides-buliding-blocks
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com